dc.contributor.author | Skinningsrud, Beate | |
dc.contributor.author | Lie, Benedicte A. | |
dc.contributor.author | Husebye, Eystein S. | |
dc.contributor.author | Kvien, Tore K. | |
dc.contributor.author | Førre, Øystein | |
dc.contributor.author | Flatø, Berit | |
dc.contributor.author | Stormyr, Alice | |
dc.contributor.author | Joner, Geir | |
dc.contributor.author | Njølstad, Pål R. | |
dc.contributor.author | Egeland, Thore | |
dc.contributor.author | Undlien, Dag E. | |
dc.date.accessioned | 2011-03-18T12:45:22Z | |
dc.date.available | 2011-03-18T12:45:22Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Skinningsrud, B., Lie, B.A., Husebye, E.S., Kvien, T.K., Førre, Ø., Flatø, B. ... Undlien, D.A. (2010). A CLEC16A variant confers risk for juvenile idiopathic arthritis and anti-cyclic citrullinated peptide antibody negative rheumatoid arthritis. Annals of the Rheumatic Diseases, 69 (8), 1471-1474 | en_US |
dc.identifier.issn | Print: 0003-4967 | |
dc.identifier.issn | Online: 1468-2060 | |
dc.identifier.other | FRIDAID 348207 | |
dc.identifier.uri | http://hdl.handle.net/10642/637 | |
dc.description.abstract | Objective Variants in CLEC16A have conferred susceptibility to autoimmune diseases in genome-wide association studies. The present work aimed to investigate the locus' involvements in juvenile idiopathic arthritis (JIA) and further explore the association with rheumatoid arthritis (RA), type 1 diabetes (T1D) and Addison's disease (AD) in the Norwegian population.
Methods Three single nucleotide polymorphisms (SNPs) were genotyped in patients with RA (n=809), JIA (n=509), T1D (n=1211) and AD (n=414) and in healthy controls (n=2149).
Results All diseases were associated with CLEC16A, but with different SNPs. The intron 22 SNP, rs6498169, was associated with RA (p=0.006) and JIA (p=0.016) and the intron 19 SNPs, rs12708716/rs12917716, with T1D (p=1×10−5) and AD (p=2×10−4). The RA association was confined to the anti-cyclic citrullinated peptide antibody (anti-CCP) negative subgroup (p=2×10−4).
Conclusion This is the first report of a CLEC16A association with JIA and a split of the RA association according to anti-CCP status. Different causative variants underlie the rheumatic versus the organ specific diseases. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | BMJ Publishing Group | en_US |
dc.relation.ispartofseries | Annals of the Rheumatic Diseases;69 (8) | |
dc.subject | Arthritis | en_US |
dc.subject | Rheumatoid arthritis | en_US |
dc.subject | VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Reumatologi: 759 | en_US |
dc.title | A CLEC16A variant confers risk for juvenile idiopathic arthritis and anti-cyclic citrullinated peptide antibody negative rheumatoid arthritis | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | BMJ Open. This article has been accepted for publication in Annals of the Rheumatic Diseases 69 (8) following peer review and can also be viewed on the journal's website at URL: http://dx.doi.org/10.1136/ard.2009.114934 | en_US |
dc.identifier.doi | http://dx.doi.org/10.1136/ard.2009.114934 | |