Patients with Opioid Use Disorder Choosing Treatment with Extended-Release Naltrexone: A 6-Month Naturalistic Study
Brenna, Ida Halvorsen; Waleur, Karin Merethe; Saltyte Benth, Jurate; Solli, Kristin Klemmetsby; Mordal, Jon; Løberg, Else-Marie; Weimand, Bente; Tanum, Lars Håkon Reiestad
Peer reviewed, Journal article
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https://hdl.handle.net/11250/3175100Utgivelsesdato
2024Metadata
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Introduction: The treatment efficacy of extended-release naltrexone (XR-NTX) for opioid use disorder (OUD) has been demonstrated in several studies, but not in naturalistic settings where opioid agonist treatment (OAT) is freely accessible. This study aimed to examine the different treatment outcomes of XR-NTX in a setting where the participants freely chose XR-NTX as a treatment option instead of OAT. Methods: This was a 24-week open-label clinical prospective cohort study conducted in an outpatient setting at five hospitals in Norway. The study included 161 participants aged 18-65 years with OUD. Intramuscular injections of XR-NTX were administered every 4 weeks for 24 weeks. Measurements included retention in treatment, reasons for treatment discontinuation, days of use of opioids, other illicit substances and alcohol, level of heroin craving, treatment satisfaction, and adverse events (AEs). Results: Of 161 included participants, the mean age was 38 years, and 24% were women; 138 received at least one d