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dc.contributor.authorUtheim, Tor Paaske
dc.contributor.authorChen, Xiangjun
dc.contributor.authorFineide, Fredrik
dc.contributor.authorSteinkjer, Tore
dc.contributor.authorHeegaard, Steffen
dc.contributor.authorKolko, Miriam
dc.contributor.authorDartt, Darlene A.
dc.contributor.authorKhan, Ayyad Ahmad Zartasht
dc.date.accessioned2024-12-06T06:52:59Z
dc.date.available2024-12-06T06:52:59Z
dc.date.created2024-10-03T13:30:33Z
dc.date.issued2024
dc.identifier.citationActa Ophthalmologica. 2024, 1-6.en_US
dc.identifier.issn1755-375X
dc.identifier.urihttps://hdl.handle.net/11250/3168618
dc.description.abstractPurpose: To examine the effectiveness and identify clinical response predictors of a short corticosteroid-based regimen consisting of topical preservative-free 0.1% dexamethasone (Monopex®, Théa Laboratories) in conjunction with artificial tears (AT) for dry eyes in a real-life clinical setting. Methods: Patients were recruited from the Norwegian Dry Eye Clinic and were allowed to use ATs of their own choice in addition to the prescribed 14- day topical dexamethasone course. Ocular Surface Disease Index (OSDI), Dry Eye Questionnaire (DEQ-5), Schirmer test (ST), fluorescein tear film break-up time (FBUT), ocular surface staining (OSS), meibum expressibility (ME), meibum quality (MQ), number of expressible meibomian glands among the central eight glands in the lower lids (NMG) and intraocular pressure (IOP) were measured at baseline and at 1-month follow-up. The average values of clinical parameters from both eyes were used for analyses. A paired t-test and a significance value of p < 0.05 were used for statistical analyses. Associations between sex, age, baseline values and the changes after the intervention (Δ) were explored using linear regression. Results: A total of 167 patients (124 women, mean age 54 years ±17 (standard deviation)) were included. One month after initiation of intervention, OSDI and DEQ5 scores improved from 39.5 ± 22.1 to 31.4 ± 21.3 (p < 0.001) and from 12.6 ± 4.2 to 11.0 ± 4.6 (p < 0.001), respectively. OSS improved from 2.2 ± 1.4 to 1.8 ± 1.5 (p < 0.001), NMG increased from 4.8 ± 2.2 to 5.1 ± 2.2 (p < 0.05), while IOP decreased from 12.9 ± 3.3 to 12.4 ± 3.5 mmHg (p < 0.05). Significant associations were found between the change in symptoms and objective measures of DED (ΔOSDI , ΔDEQ5, ΔOSS , ΔFBUT, ΔN MG , ΔMQ ) and their respective baseline values (OSDI, DEQ5, OSS, FBUT, N MG , MQ). The remaining tests did not show statistically significant changes. Conclusion: Improvement in dry eye symptoms and signs were observed follow-ing a short course of topical, preservative-free 0.1% dexamethasone treatment in combination with AT. Individuals exhibiting more pronounced symptoms and signs witnessed the most profound improvements with the treatment regimen, suggesting that poor baseline parameters may serve as response predictors of the treatment regimen. While the real-life data presented herein are valuable, the conclusions are limited by the inherent biases of a non-controlled study.en_US
dc.language.isoengen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.titleResponse predictors of a topical corticosteroid-based regimen for dry eyes: A real-life studyen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1111/aos.16758
dc.identifier.cristin2309129
dc.source.journalActa Ophthalmologicaen_US
dc.source.pagenumber1-6en_US


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal