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dc.contributor.authorTsuruda, Kaitlyn
dc.contributor.authorHovda, Tone
dc.contributor.authorBhargava, Sameer
dc.contributor.authorVeierød, Marit Bragelien
dc.contributor.authorHofvind, Solveig
dc.date.accessioned2020-11-15T16:17:19Z
dc.date.accessioned2021-02-11T09:56:50Z
dc.date.available2020-11-15T16:17:19Z
dc.date.available2021-02-11T09:56:50Z
dc.date.issued2020-11-12
dc.identifier.citationTsuruda M, Hovda T, Bhargava S, Veierød MB, Hofvind S. Survival among women diagnosed with screen-detected or interval breast cancer classified as true, minimal signs, or missed through an informed radiological review. European Radiology. 2020en
dc.identifier.issn0938-7994
dc.identifier.issn1432-1084
dc.identifier.urihttps://hdl.handle.net/10642/9522
dc.description.abstractObjectives: “True” breast cancers, defined as not being visible on prior screening mammograms, are expected to be more aggressive than “missed” cancers, which are visible in retrospect. However, the evidence to support this hypothesis is limited. We compared the risk of death from any cause for women with true, minimal signs, and missed invasive screen-detected (SDC) and interval breast cancers (IC). Methods: This nation-wide study included 1022 SDC and 788 IC diagnosed through BreastScreen Norway during 2005–2016. Cancers were classified as true, minimal signs, or missed by five breast radiologists in a consensus-based informed review of prior screening and diagnostic images. We used multivariable Cox regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the risk of death from any cause associated with true, minimal signs, and missed breast cancers, adjusting for age at diagnosis, histopathologic tumour diameter and grade, and subtype. Separate models were created for SDC and IC. Results: Among SDC, 463 (44%) were classified as true and 242 (23%) as missed; among IC, 325 (39%) were classified as true and 235 (32%) missed. Missed SDC were associated with a similar risk of death as true SDC (HR = 1.20, 95% CI (0.49, 2.46)). Similar results were observed for missed versus true IC (HR = 1.31, 95% CI (0.77, 2.23)). Conclusions: We did not observe a statistical difference in the risk of death for women diagnosed with true or missed SDC or IC; however, the number of cases reviewed and follow-up time limited the precision of our estimates.en
dc.description.sponsorshipOpen Access funding provided by the University of Oslo (incl Oslo University Hospital). This study received funding from the Dam Foundation via the Norwegian Breast Cancer Society (2018/FO201362).en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.ispartofseriesEuropean Radiology;
dc.relation.urihttps://link.springer.com/article/10.1007/s00330-020-07340-4
dc.rightsCreative Commons Attribution 4.0 International (CC BY 4.0) Licenseen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBreast neoplasmsen
dc.subjectMammographyen
dc.subjectMass screeningen
dc.subjectSurvival ratesen
dc.subjectEarly detectionen
dc.subjectCanceren
dc.titleSurvival among women diagnosed with screen-detected or interval breast cancer classified as true, minimal signs, or missed through an informed radiological reviewen
dc.typeJournal article
dc.typePeer revieweden
dc.date.updated2020-11-15T16:17:19Z
dc.description.versionpublishedVersionen
dc.subject.hrcsKreft: Befolkningsundersøkelser
dc.subject.hrcsCancer : Population screening
dc.identifier.doihttps://doi.org/10.1007/s00330-020-07340-4
dc.identifier.cristin1847348
dc.source.journalEuropean Radiology
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Radiologi og bildediagnostikk: 763
dc.subject.nsiVDP::Midical sciences: 700::Clinical medical sciences: 750::Radiology and diagnostic imaging: 763
dc.relation.projectIDStiftelsen Dam: 2018/FO201362


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