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dc.contributor.authorBjelland, Elisabeth Krefting
dc.contributor.authorGran, Jon Michael
dc.contributor.authorHofvind, Solveig
dc.contributor.authorEskild, Anne
dc.date.accessioned2020-02-17T09:21:54Z
dc.date.accessioned2020-02-18T11:53:50Z
dc.date.available2020-02-17T09:21:54Z
dc.date.available2020-02-18T11:53:50Z
dc.date.issued2019-09-10
dc.identifier.citationBjelland EK, Gran JM, Hofvind S, Eskild A. The association of birthweight with age at natural menopause: a population study of women in Norway. International Journal of Epidemiology. 2019:1-9en
dc.identifier.issn0300-5771
dc.identifier.issn0300-5771
dc.identifier.issn1464-3685
dc.identifier.urihttps://hdl.handle.net/10642/8133
dc.description.abstractBackground: Previous studies suggest that birthweight may influence age at natural menopause, but the evidence remains inconclusive. Thus, we aimed to estimate the association of birthweight with age at natural menopause. Methods: A retrospective population study of 164 608 women in Norway, aged 48–71years. Data were obtained by two self-administered questionnaires among participants in BreastScreen Norway during 2006–2014. We used Cox proportional hazard models to estimate hazard ratios and logistic regression models to estimate odds ratios of menopause according to birthweight. Restricted cubic splines were applied to allow for possible non-linear associations, and adjustments were made for year and country of birth. Results: Women with birthweight <2500g were median 51years at menopause (interquartile range 49–54years), whereas women with birthweight 3500–3999g were median 52years at menopause (interquartile range 49–54years). The hazard ratio of menopause decreased with increasing birthweight up until 3500g. At birthweights >3500g, we estimated no further decrease (P for non-linearity ¼ 0.007). Birthweight at 2500g increased the odds ratios of menopause before the age of 45 [1.20; 95% confidence interval (CI): 1.14–1.25] and the age of 40 (1.26; 95% CI: 1.15–1.38) compared with birthweight at 3500g. At birthweights 4000g and 4500g, the odds ratio estimates were very similar to the reference group and the CIs overlapped 1.00. Conclusions: We found a non-linear dose-relationship of birthweight with age at natural menopause, and low birthweight was associated with early natural menopause.en
dc.description.sponsorshipThis work was supported by the Norwegian Cancer Society [grant number 6863294-2015 to E.K.B.].en
dc.language.isoenen
dc.publisherOxford University Press (OUP)en
dc.relation.ispartofseriesInternational Journal of Epidemiology;Published 21 October 2019
dc.relation.urihttps://academic.oup.com/ije/advance-article/doi/10.1093/ije/dyz207/5601469
dc.rights© The Author(s) 2019. Published by Oxford University Press on behalf of the International Epidemiological Association. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/ by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contactjournals.permissions@oup.comen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMenopause agesen
dc.subjectBirthweightsen
dc.subjectEarly menopauseen
dc.subjectGrowth restrictionsen
dc.subjectPopulation studiesen
dc.subjectPrimary ovarian insufficienciesen
dc.titleThe association of birthweight with age at natural menopause: a population study of women in Norwayen
dc.typeJournal articleen
dc.typePeer revieweden
dc.date.updated2020-02-17T09:21:54Z
dc.description.versionpublishedVersionen
dc.identifier.doihttps://dx.doi.org/10.1093/ije/dyz207
dc.identifier.cristin1775205
dc.source.journalInternational Journal of Epidemiology
dc.relation.projectIDKreftforeningen: 6863294-2015


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© The Author(s) 2019. Published by Oxford University Press on behalf of the International Epidemiological Association. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/ by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contactjournals.permissions@oup.com
Med mindre annet er angitt, så er denne innførselen lisensiert som © The Author(s) 2019. Published by Oxford University Press on behalf of the International Epidemiological Association. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/ by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contactjournals.permissions@oup.com