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dc.contributor.authorOssum, Alvilde Maria
dc.contributor.authorPalm, Øyvind
dc.contributor.authorSmåstuen, Milada C
dc.contributor.authorBernklev, Tomm
dc.contributor.authorJahnsen, Jørgen
dc.contributor.authorMoum, Bjørn
dc.contributor.authorHøivik, Marte Lie
dc.date.accessioned2020-01-25T16:12:32Z
dc.date.accessioned2020-02-10T14:25:20Z
dc.date.available2020-01-25T16:12:32Z
dc.date.available2020-02-10T14:25:20Z
dc.date.issued2019-05-25
dc.identifier.citationOssum AM, Palm Ø, Småstuen MC, Bernklev T, Jahnsen J, Moum B, Høivik ML. The Impact of Spondyloarthritis and Joint Symptoms on Health-Related Quality of Life and Fatigue in IBD Patients. Results From a Population-Based Inception Cohort (20-Year Follow-up in the Ibsen Study) . Inflammatory Bowel Diseases. 2019en
dc.identifier.issn1078-0998
dc.identifier.issn1078-0998
dc.identifier.issn1536-4844
dc.identifier.urihttps://hdl.handle.net/10642/8098
dc.description.abstractBackground: Patients with inflammatory bowel disease (IBD) often suffer from musculoskeletal manifestations. Health-related quality of life (HRQoL) and fatigue are known to be associated with IBD activity and musculoskeletal complaints. The aim of this study was to determine the association between spondyloarthritis, arthralgia, or back pain and the patient-reported outcomes of HRQoL and fatigue in IBD patients 20 years after their diagnosis. Methods: The IBSEN cohort was followed prospectively for 20 years. At the 20-year follow-up, the patients answered detailed questionnaires regarding rheumatological manifestations, intestinal symptoms, HRQoL, and fatigue. Multiple regression analyses were used to evaluate associations between spondyloarthritis or joint symptoms and HRQoL or fatigue. Sex, IBD diagnosis, and age were included in all the multiple regression models, in addition to other clinically relevant confounders. Results: In total, 441 patients (94%) completed the questionnaires at the 20-year follow-up. The criteria for spondyloarthritis (axial or peripheral) were fulfilled in 158 patients (36%), current back pain during the previous 3 months was reported by 79 patients (18%), and current arthralgia was reported by 178 patients (40%). Current back pain and arthralgia were independently associated with lower HRQoL, higher levels of fatigue, and chronic fatigue. A diagnosis of spondyloarthritis was not associated with reduced HRQoL or fatigue when adjusted for possible confounders. Conclusions: Current joint symptoms in IBD patients 20 years after diagnosis were associated with poorer HRQoL, higher levels of fatigue, and chronic fatigue, whereas spondyloarthritis did not impact HRQoL or fatigue negatively in this cohort.en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.ispartofseriesInflammatory Bowel Diseases;Volume 26, Issue 1, January 2020
dc.rightsThis is a pre-copyedited, author-produced version of an article accepted for publication in Inflammatory Bowel Diseases following peer review. The version of recordInflammatory Bowel Diseases, Volume 26, Issue 1, January 2020, Pages 114–124, is available online at: https://dx.doi.org/10.1093/ibd/izz105 / https://academic.oup.com/ibdjournal/article/26/1/114/5498705en
dc.subjectInflammatory bowel diseasesen
dc.subjectArthritisen
dc.subjectSpondyloarthritisen
dc.subjectLife qualitiesen
dc.subjectFatigueen
dc.titleThe Impact of Spondyloarthritis and Joint Symptoms on Health-Related Quality of Life and Fatigue in IBD Patients. Results From a Population-Based Inception Cohort (20-Year Follow-up in the Ibsen Study)en
dc.typeJournal articleen
dc.typePeer revieweden
dc.date.updated2020-01-25T16:12:31Z
dc.description.versionacceptedVersionen
dc.identifier.doihttps://dx.doi.org/10.1093/ibd/izz105
dc.identifier.cristin1701763
dc.source.journalInflammatory Bowel Diseases


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