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dc.contributor.authorSequeira, Joao
dc.contributor.authorLouca, Jorge
dc.contributor.authorMendes, Antonio
dc.contributor.authorLind, Pedro
dc.date.accessioned2020-01-03T08:19:01Z
dc.date.accessioned2020-01-10T14:18:18Z
dc.date.available2020-01-03T08:19:01Z
dc.date.available2020-01-10T14:18:18Z
dc.date.issued2019-09-26
dc.identifier.citationSequeira, Louca, Mendes, Lind P. Transition from endemic behavior to eradication of malaria due to combined drug therapies: an agent-model approach. Journal of Theoretical Biology. 2019;484(110030)en
dc.identifier.issn0022-5193
dc.identifier.issn0022-5193
dc.identifier.issn1095-8541
dc.identifier.urihttps://hdl.handle.net/10642/7967
dc.description.abstractWe introduce an agent-based model describing a susceptible-infectious-susceptible (SIS) system of humans and mosquitoes to predict malaria epidemiological scenarios in realistic biological conditions. Emphasis is given to the transition from endemic behavior to eradication of malaria transmission induced by combined drug therapies acting on both the gametocytemia reduction and on the selective mosquito mortality during parasite development in the mosquito. Our mathematical framework enables to uncover the critical values of the parameters characterizing the effect of each drug therapy. Moreover, our results provide quantitative evidence of what was up to now only partially assumed with empirical support: interventions combining gametocytemia reduction through the use of gametocidal drugs, with the selective action of ivermectin during parasite development in the mosquito, may actively promote disease eradication in the long run. In the agent model, the main properties of human-mosquito interactions are implemented as parameters and the model is validated by comparing simulations with real data of malaria incidence collected in the endemic malaria region of Chimoio in Mozambique. Finally, we discuss our findings in light of current drug administration strategies for malaria prevention, which may interfere with human-to-mosquito transmission process.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.ispartofseriesJournal of Theoretical Biology;Volume 484, 7 January 2020, 110030
dc.rights© 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMalaria spreadingsen
dc.subjectAgent modelsen
dc.subjectGametocytemiaen
dc.subjectTransmission controlen
dc.subjectPrimaquineen
dc.subjectMethylene blueIvermectinen
dc.subjectTransmission mitigation
dc.titleTransition from endemic behavior to eradication of malaria due to combined drug therapies: an agent-model approachen
dc.typeJournal articleen
dc.typePeer revieweden
dc.date.updated2020-01-03T08:19:01Z
dc.description.versionacceptedVersionen
dc.identifier.doihttps://dx.doi.org/10.1016/j.jtbi.2019.110030
dc.identifier.cristin1748267
dc.source.journalJournal of Theoretical Biology


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© 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Except where otherwise noted, this item's license is described as © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/