dc.contributor.author | Garcia-Hidalgo, Catalina | |
dc.contributor.author | Cheung, Po-Yin | |
dc.contributor.author | Vento, Máximo | |
dc.contributor.author | O´Reilly, Megan | |
dc.contributor.author | Saugstad, Ola Didrik | |
dc.contributor.author | Schmölzer, Georg M. | |
dc.date.accessioned | 2019-07-24T07:48:07Z | |
dc.date.available | 2019-07-24T07:48:07Z | |
dc.date.issued | 2018-12-18 | |
dc.identifier.citation | Garcia-Hidalgo, C., Cheung, P. Y., Solevåg, A. L., Vento, M., O'Reilly, M., Saugstad, O., & Schmolzer, G. (2018). A review of oxygen use during chest compressions in newborns. Frontiers in pediatrics, 6, 400. | en |
dc.identifier.issn | 2296-2360 | |
dc.identifier.uri | https://hdl.handle.net/10642/7339 | |
dc.description.abstract | Background: International consensus statements for resuscitation of newborn infants recommend provision of 100% oxygen once chest compressions are required. However, 100% oxygen exacerbates reperfusion injury and reduces cerebral perfusion in newborn babies.
Objective: We aimed to establish whether resuscitation with air during chest compression is feasible and safe in newborn infants compared with 100% oxygen.
Methods: Systematic search of PubMed, Google Scholar and CINAHL for articles examining variable oxygen concentrations during chest compressions in term newborns.
Results: Overall, no human studies but eight animal studies (n = 323 animals) comparing various oxygen concentrations during chest compression were identified. The pooled analysis showed no difference in mortality rates for animals resuscitated with air vs. 100% oxygen (risk ratio 1.04 [0.35, 3.08], I2 = 0%, p = 0.94). ROSC was also similar between groups with a mean difference of −3.8 [−29.7–22] s, I2 = 0%, p = 0.77. No difference in oxygen damage or adverse events were identified between groups.
Conclusions: Air had similar time to ROSC and mortality as 100% oxygen during neonatal chest compression. A large randomized controlled clinical trial comparing air vs. 100% oxygen during neonatal chest compression is warranted. | en |
dc.language.iso | en | en |
dc.publisher | Frontiers Media S.A. | en |
dc.relation.ispartofseries | Frontiers in pediatrics;6 | |
dc.rights | Attribution 3.0 United States
This is an open access article, originally published at https://doi.org/10.3389/fped.2018.00400 | en |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject | Artikkel | en |
dc.subject | VDP::Medisinske Fag: 700 | en |
dc.title | A review of oxygen use during chest compressions in Newborns-A meta-analysis of animal data | en |
dc.type | Journal article | en |
dc.type | Peer reviewed | en |
dc.description.version | publishedVersion | en |
dc.identifier.doi | https://doi.org/10.3389/fped.2018.00400 | |
dc.identifier.cristin | 1671582 | |