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dc.contributor.authorSmogeli, Aud Elisabeth Farstad
dc.contributor.authorSmåstuen, Milada Cvancarova
dc.contributor.authorWang, Yun
dc.contributor.authorDavidson, Ben
dc.contributor.authorKristensen, Gunnar S Balle
dc.contributor.authorLindemann, Kristina
dc.date.accessioned2019-04-15T09:47:34Z
dc.date.accessioned2019-05-24T09:03:43Z
dc.date.available2019-04-15T09:47:34Z
dc.date.available2019-05-24T09:03:43Z
dc.date.issued2018-11-01
dc.identifier.citationSmogeli AEF, Småstuen MC, Wang Y, Davidson B, Kristensen GSB, Lindemann K. Clinical Outcome of Patients with High-Risk Endometrial Carcinoma after Treatment with Chemotherapy only. International Journal of Gynecological Cancer. 2018;28(9):1789-1795en
dc.identifier.issn1048-891X
dc.identifier.issn1048-891X
dc.identifier.issn1525-1438
dc.identifier.urihttps://hdl.handle.net/10642/7160
dc.description.abstractObjectives: Adjuvant treatment of high-risk endometrial cancer (EC) is still controversial. Several studies have tried to clarify the best treatment strategy, and guidelines have been made, but no study to date has shown a survival benefit for radiation over chemotherapy. We aimed to evaluate the outcome of high-risk EC patients treated with adjuvant chemotherapy only in a population where the routine administration of adjuvant radiotherapy was omitted. Methods/Materials: This is a retrospective study including 230 EC patients with FIGO stage I type II, Ib type I/G3, stage II and IIIc treated at the Oslo University Hospital between 2005-2012. Standard treatment was hysterectomy, bilateral salphingo-ooforectomy and at least pelvic lymphadenectomy followed by adjuvant chemotherapy. Results: Of the 230 high-risk patients patients, standard treatment was given to 146 patients (63.5%); 60 patients in stage I, 10 patients in stage II and 76 patients in stage IIIc. Only 10% of patients with stage I disease relapsed, with 3.3% loco-regional relapses and 6.7% distant relapses. Recurrence rate in stage IIIc was 39.5%, with 7.9% isolated vaginal and 31.6% distant relapses. The 3-year DFS was 92% for stage I, 80% for stage II and 60% for stage IIIc disease. In the total population, 55 patients had FIGO stage Ia, 43 Ib, 42 stage II, and 90 IIIc disease. Recurrence rate in the total population was 29.6%, with 9.6% isolated vaginal recurrences, 1.7% recurrences located in the pelvis and 18.3% distant recurrences. Conclusions: Patients with high-risk EC have acceptable vaginal/pelvic control rates after adjuvant chemotherapy. However, prognosis remains poor for patients with stage IIIc disease, also after chemotherapy.en
dc.language.isoenen
dc.publisherBMJ Publishing Groupen
dc.relation.ispartofseriesInternational Journal of Gynecological Cancer;Volume 28, Issue 9
dc.rights© 2018 by IGCS and ESGO. Reuse of this manuscript version (excluding any databases, tables, diagrams, photographs and other images or illustrative material included where another copyright owner is identified) is permitted strictly pursuant to the terms of the Creative Commons Attribution-Non Commercial 4.0 International, https://creativecommons.org/licenses/by-nc/4.0/.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectEndometrial canceren
dc.subjectHigh risksen
dc.subjectRadiotherapiesen
dc.subjectAdjuvant chemotherapiesen
dc.subjectRecurrencesen
dc.subjectSurvivalsen
dc.titleClinical Outcome of Patients with High-Risk Endometrial Carcinoma after Treatment with Chemotherapy onlyen
dc.typeJournal articleen
dc.typeJournal article
dc.typePeer revieweden
dc.date.updated2019-04-15T09:47:34Z
dc.description.versionacceptedVersionen
dc.identifier.doi10.1097/IGC.0000000000001356
dc.identifier.doihttp://dx.doi.org/10.1097/IGC.0000000000001356
dc.identifier.cristin1644747
dc.source.journalInternational Journal of Gynecological Cancer


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© 2018 by IGCS and ESGO. Reuse of this manuscript version (excluding any databases, tables, diagrams, photographs and other images or illustrative material included where another copyright owner is identified) is permitted strictly pursuant to the terms of the Creative Commons Attribution-Non Commercial 4.0 International, https://creativecommons.org/licenses/by-nc/4.0/.
Med mindre annet er angitt, så er denne innførselen lisensiert som © 2018 by IGCS and ESGO. Reuse of this manuscript version (excluding any databases, tables, diagrams, photographs and other images or illustrative material included where another copyright owner is identified) is permitted strictly pursuant to the terms of the Creative Commons Attribution-Non Commercial 4.0 International, https://creativecommons.org/licenses/by-nc/4.0/.