Blar i TKD - Institutt for maskin, elektronikk og kjemi på emneord "Multiple sclerosis"
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CD8 + T cell gene expression analysis identifies differentially expressed genes between multiple sclerosis patients and healthy controls
(Multiple Sclerosis Journal, Experimental, Translational and Clinical;Volume: 6, issue: 4, Journal article; Peer reviewed, 2020-12-09)Background: Genetic and clinical observations have indicated T cells are involved in MS pathology. There is little insight in how T cells are involved and whether or not these can be used as markers for MS. Objectives: ... -
Exploring the role of the multiple sclerosis susceptibility gene CLEC16A in T cells
(Scandinavian Journal of Immunology;, Peer reviewed; Journal article, 2021-05-02)C-type lectin-like domain family 16 member A (CLEC16A) is associated with autoimmune disorders, including multiple sclerosis (MS), but its functional relevance is not completely understood. CLEC16A is expressed in several ... -
Humoral immunity to SARS-CoV-2 mRNA vaccination in multiple sclerosis: the relevance of time since last rituximab infusion and first experience from sporadic revaccinations
(Journal of Neurology, Neurosurgery and Psychiatry;, Peer reviewed; Journal article, 2021-10-20)Introduction: The effect of disease-modifying therapies (DMT) on vaccine responses is largely unknown. Understanding the development of protective immunity is of paramount importance to fight the COVID-19 pandemic. Objective: ... -
Impact of treatment on cellular immunophenotype in MS: A cross-sectional study
(Neurology, Neuroimmunology and Neuroinflammation;volume 7, issue 3, Journal article; Peer reviewed, 2020-03-05)Objective: To establish cytometry profiles associated with disease stages and immunotherapy in MS. Methods: Demographic/clinical data and peripheral blood samples were collected from 227 patients with MS and 82 sex- and ... -
Increased DNA methylation of SLFN12 in CD4+ and CD8+ T cells from multiple sclerosis patients
(PLoS ONE;13 (10): e0206511, Journal article; Journal article; Peer reviewed, 2018-10-31)DNA methylation is an epigenetic mark that is influenced by environmental factors and is associated with changes to gene expression and phenotypes. It may link environmental exposures to disease etiology or indicate important ... -
No differential gene expression for CD4+ T cells of MS patients and healthy controls.
(Multiple Sclerosis Journal - Experimental, Translational and Clinical;Volume 5(2), Journal article; Peer reviewed, 2019-05-20)Background: Multiple sclerosis-associated genetic variants indicate that the adaptive immune system plays an important role in the risk of developing multiple sclerosis. It is currently not well understood how these multiple ... -
Quantitative proteomic analyses of CD4+ and CD8+ T cells reveal differentially expressed proteins in multiple sclerosis patients and healthy controls
(Clinical Proteomics;16, Article number: 19 (2019), Peer reviewed; Journal article, 2019-04-27)Background: Multiple sclerosis (MS) is an autoimmune, neuroinflammatory disease, with an unclear etiology. How‑ ever, T cells play a central role in the pathogenesis by crossing the blood–brain‑barrier, leading to inflammation ... -
A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis
(Nature Communications;10, Article number: 2236 (2019), Journal article; Peer reviewed, 2019-05-20)Genome-wide association studies (GWAS) have identified more than 50,000 unique associations with common human traits. While this represents a substantial step forward, establishing the biology underlying these associations ... -
A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis.
(Nature Communications;10, Article number: 2236 (2019), Journal article; Peer reviewed, 2019-03-26)Genome-wide association studies (GWAS) have identified more than 50,000 unique associations with common human traits. While this represents a substantial step forward, establishing the biology underlying these associations ...