Blar i HV - Institutt for naturvitenskapelige helsefag på emneord "Testicular cancer"

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    • Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor 

      Litchfield, Kevin; Levy, Max; Orlando, Giulia; Loveday, Chey; Law, Philip J.; Migliorini, Gabriele; Holroyd, Amy; Broderick, Peter; Karlsson, Robert; Haugen, Trine B.; Kristiansen, Wenche; Nsengimana, Jérémie; Fenwick, Kerry; Assiotis, Ioannis; Kote-Jarai, Zsofia; Dunning, Alison M.; Muir, Kenneth; Peto, Julian; Eeles, Rosalind; Easton, Douglas F.; Dudakia, Darshna; Orr, Nick; Pashayan, Nora; Bishop, D. Timothy; Reid, Alison; Huddart, Robert A.; Shipley, Janet; Grotmol, Tom; Wiklund, Fredrik; Houlston, Richard S.; Turnbull, Clare (Nature Genetics;Volume 49, Issue 7, Journal article; Peer reviewed, 2017-06-12)
      Genome-wide association studies (GWAS) have transformed our understanding of testicular germ cell tumour (TGCT) susceptibility but much of the heritability remains unexplained. Here we report a new GWAS, a meta-analysis ...

    • Profiling of the small RNA populations in human testicular germ cell tumors shows global loss of piRNAs 

      Rounge, Trine Ballestad; Furu, Kari; Skotheim, Rolf Inge; Haugen, Trine B.; Grotmol, Tom; Enerly, Espen (Journal article; Peer reviewed, 2015)
      Background Small non-coding RNAs play essential roles in gene regulation, however, the interplay between RNA groups, their expression levels and deregulations in tumorigenesis requires additional exploration. In particular, ...

    • Serum RNA profiling in the 10-year period prior to diagnosis of testicular germ cell tumour 

      Burton, Joshua; Umu, Sinan Uğur; Langseth, Hilde; Grotmol, Tom; Grimsrud, Tom Kristian; Haugen, Trine B.; Rounge, Trine Ballestad (Frontiers in Oncology;volume 10, Peer reviewed; Journal article, 2020-10-28)
      Although testicular germ cell tumor (TGCT) overall is highly curable, patients may experience late effects after treatment. An increased understanding of the mechanisms behind the development of TGCT may pave the way for ...