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dc.contributor.authorBacon, Kathryn
dc.contributor.authorSegal, Neil A.
dc.contributor.authorØiestad, Britt Elin
dc.contributor.authorLewis, Cara
dc.contributor.authorNevitt, Michael
dc.contributor.authorBrown, Carrie
dc.contributor.authorLaValley, Michael
dc.contributor.authorMcCulloch, CE
dc.contributor.authorFelson, David T
dc.date.accessioned2019-01-08T02:38:27Z
dc.date.accessioned2019-03-04T09:58:06Z
dc.date.available2019-01-08T02:38:27Z
dc.date.available2019-03-04T09:58:06Z
dc.date.issued2018-08-29
dc.identifier.citationBacon K, Segal NA, Øiestad BE, Lewis, Nevitt M, Brown C, LaValley M, McCulloch, Felson DT. Thresholds in the relationship of quadriceps strength with functional limitations in women with knee osteoarthritis.. Arthritis care & research. 2018en
dc.identifier.issn2151-4658
dc.identifier.issn2151-4658
dc.identifier.urihttps://hdl.handle.net/10642/6704
dc.description.abstractObjective: To investigate thresholds of strength below which people with knee osteoarthritis (OA) may have more difficulty carrying out physical functions of daily life. Persons below such thresholds might benefit more from strengthening interventions than those with greater strength. Methods: We studied persons with symptomatic OA at baseline in the Multicenter Osteoarthritis Study (MOST) who had knee extensor strength measured isokinetically at 60o/sec. Subjects underwent a 20-Meter walk test, a Sit-to-Stand Test and answered the WOMAC. Physical function results were plotted against measures of quadriceps strength (newton-meters, Nm) (and as strength/body weight) for the worse knee. Locally weighted regression scatterplot smoothers (LOESS) were examined for inflection points. Nonlinear relationships were examined in piecewise linear regression models. Differences were tested using linear and logistic regression models. Results: 834 participants (65.8% women) were on average 62.9(±7.9) years old. In women, there were thresholds of strength below which the slope of strength vs. function was steeper: walking speed (<58Nm), chair stand time (<32Nm) and WOMAC functions rising from a chair and getting on/off the toilet (<38Nm). We found no thresholds in men. LOESS analyses using strength/weight showed similar results. Conclusions: In persons with symptomatic knee OA, thresholds in the strength function relationship may help identify individuals, especially women, at the brink of disability insofar as strength and daily tasks. In those with low strength, small increments in strength may be associated with improvement in function and greater ease with common daily life, emphasizing the importance of preventing loss of strength.en
dc.description.sponsorshipGrants P60 AR047785 NIAMS Multidisciplinary Clinical Research Center; NIAU01AG18820, U01AG18832, U01AG18947 and U01AG19069; Multicenter Osteoarthritis Study (MOST) Second Renewal; NIAMS 5 T32AR 7598-18 Rheumatology Training Grant.en
dc.language.isoenen
dc.publisherWileyen
dc.relation.ispartofseriesArthritis care & research;
dc.rightsThis article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/acr.23740 This article is protected by copyright. All rights reserveden
dc.subjectStrength thresholdsen
dc.subjectQuadriceps strengthen
dc.subjectFunctional limitationsen
dc.subjectKnee osteoarthritisen
dc.titleThresholds in the relationship of quadriceps strength with functional limitations in women with knee osteoarthritisen
dc.typeJournal articleen
dc.typePeer revieweden
dc.date.updated2019-01-08T02:38:27Z
dc.description.versionacceptedVersionen
dc.identifier.doihttp://dx.doi.org/10.1002/acr.23740
dc.source.journalArthritis care & research


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