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dc.contributor.authorSletner, Line
dc.contributor.authorJenum, Anne Karen
dc.contributor.authorYajnik, Chittaranjan S
dc.contributor.authorMørkrid, Kjersti
dc.contributor.authorNakstad, Britt
dc.contributor.authorJensen, Odd H.
dc.contributor.authorBirkeland, Kåre I.
dc.contributor.authorVangen, Siri
dc.date.accessioned2018-01-30T19:13:47Z
dc.date.accessioned2018-04-16T14:14:19Z
dc.date.available2018-01-30T19:13:47Z
dc.date.available2018-04-16T14:14:19Z
dc.date.issued2017
dc.identifier.citationSletner L, Jenum AK, Yajnik CS, Mørkrid K, Nakstad B, Jensen OH, Birkeland KI, Vangen S. Fetal growth trajectories in pregnancies of European and South Asian mothers with and without gestational diabetes, a population-based cohort study. PLoS ONE. 2017;12(3)en
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10642/5902
dc.description.abstractObjective Our aim was to examine the impact of gestational diabetes (GDM), from before the GDM-diagnosis is made, on fetal growth trajectories, and to compare it in Europeans and South Asians; two ethnic groups with dissimilar fetal growth patterns. Methods We studied European (n = 349) and South Asian (n = 184) pregnant women, from the population-based STORK-Groruddalen cohort in Oslo, Norway. Mothers were enrolled in early pregnancy, screened for GDM in gestational week 28 ±2, and classified as “non-GDM”, “mild GDM” or “moderate/severe GDM”. We measured fetal head circumference, abdominal circumference and femur length by ultrasound, and estimated fetal weight in gestational week 24, 32 and 37, and performed corresponding measurements at birth. Results In non-GDM pregnancies, South Asian fetuses (n = 156) had a slower growth from gestational week 24, compared with Europeans (n = 310). More than two thirds of the European mothers later diagnosed with GDM were overweight or obese in early pregnancy, while this was not observed in South Asians. Fetuses of GDM mothers tended to be smaller than fetuses of non-GDM mothers in week 24, but thereafter grew faster until birth. This pattern was especially pronounced in fetuses of South Asian mothers with moderate/severe GDM. In week 24 these fetuses had a -0.95 SD (95% CI: -1.53, -0.36) lower estimated fetal weight than their non-GDM counterparts. In contrast, at birth they were 0.45 SD (0.09, 0.81) larger. Conclusions Offspring of GDM mothers were smaller in mid pregnancy, but subsequently grew faster until birth, compared with offspring of non-GDM mothers. This pattern was most prominent in South Asian mothers with moderate to severe GDM. However, the most remarkable characteristic of these fetuses was not a large size at birth, but the small size in mid pregnancy, before the GDM diagnosis was set.en
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.relation.urihttp://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0172946&type=printable
dc.rightsCopyright: © 2017 Sletner et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricte d use, distribu tion, and reproduction in any medium, provided the original author and source are credited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPregnancyen
dc.subjectBirthen
dc.subjectFetusesen
dc.subjectBirth weighten
dc.subjectEuropeen
dc.subjectGestational diabetesen
dc.subjectDiabetes mellitusen
dc.subjectFemuren
dc.titleFetal growth trajectories in pregnancies of European and South Asian mothers with and without gestational diabetes, a population-based cohort studyen
dc.typeJournal articleen
dc.typePeer revieweden
dc.date.updated2018-01-30T19:13:47Z
dc.description.versionpublishedVersionen
dc.identifier.doihttp://doi.org/10.1371/journal.pone.0172946
dc.identifier.cristin1465524
dc.source.journalPLoS ONE


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Copyright:
©
2017
Sletner
et al. This is an open
access
article
distributed
under
the terms
of the
Creative
Commons
Attribution
License,
which
permits
unrestricte
d use, distribu
tion, and
reproduction
in any medium,
provided
the original
author
and source
are credited.
Med mindre annet er angitt, så er denne innførselen lisensiert som Copyright: © 2017 Sletner et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricte d use, distribu tion, and reproduction in any medium, provided the original author and source are credited.