Effects of a healthy Nordic diet on gene expression changes in peripheral blood mononuclear cells in response to an oral glucose tolerance test in subjects with metabolic syndrome: A SYSDIET sub-study
dc.contributor.author | Leder, Lena | |
dc.contributor.author | Kolehmainen, Marjukka | |
dc.contributor.author | Narverud, Ingunn | |
dc.contributor.author | Dahlman, Ingrid | |
dc.contributor.author | Myhrstad, Mari | |
dc.contributor.author | De Mello, Vanessa D. | |
dc.contributor.author | Paananen, Jussi | |
dc.contributor.author | Carlberg, Carsten | |
dc.contributor.author | Schwab, Ursula | |
dc.contributor.author | Herzig, Karl-Heinz | |
dc.contributor.author | Cloetens, Lieselotte | |
dc.contributor.author | Storm, Matilda Ulmius | |
dc.contributor.author | Hukkanen, Janne | |
dc.contributor.author | Savolainen, Markku J. | |
dc.contributor.author | Rosqvist, Fredrik | |
dc.contributor.author | Hermansen, Kjeld | |
dc.contributor.author | Dragsted, Lars O. | |
dc.contributor.author | Gunnarsdóttir, Ingibjörg | |
dc.contributor.author | Thórsdóttir, Inga | |
dc.contributor.author | Risérus, Ulf | |
dc.contributor.author | Åkesson, Björn | |
dc.contributor.author | Thoresen, Magne | |
dc.contributor.author | Arner, Peter | |
dc.contributor.author | Poutanen, Kaisa S. | |
dc.contributor.author | Uusitupa, Matti | |
dc.contributor.author | Holven, Kirsten Bjørklund | |
dc.contributor.author | Ulven, Stine Marie | |
dc.date.accessioned | 2017-05-03T11:23:47Z | |
dc.date.accessioned | 2017-05-15T08:36:52Z | |
dc.date.available | 2017-05-03T11:23:47Z | |
dc.date.available | 2017-05-15T08:36:52Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Leder L, Kolehmainen M, Narverud I, Dahlman I, Myhrstad MC, De Mello, Paananen J, Carlberg C, Schwab U, Herzig K, Cloetens, Storm, Hukkanen J, Savolainen MJ, Rosqvist F, Hermansen K, Dragsted LO, Gunnarsdóttir, Thórsdóttir I, Risérus U, Åkesson, Thoresen M, Arner P, Poutanen KS, Uusitupa M, Holven KB, Ulven S. Effects of a healthy Nordic diet on gene expression changes in peripheral blood mononuclear cells in response to an oral glucose tolerance test in subjects with metabolic syndrome: A SYSDIET sub-study. Genes & Nutrition. 2016;11 | language |
dc.identifier.issn | 1555-8932 | |
dc.identifier.issn | 1865-3499 | |
dc.identifier.uri | https://hdl.handle.net/10642/4950 | |
dc.description.abstract | Background: Diet has a great impact on the risk of developing features of metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and cardiovascular diseases (CVD). We evaluated whether a long-term healthy Nordic diet (ND) can modify the expression of inflammation and lipid metabolism-related genes in peripheral blood mononuclear cells (PBMCs) during a 2-h oral glucose tolerance test (OGTT) in individuals with MetS. Methods: A Nordic multicenter randomized dietary study included subjects (n = 213) with MetS, randomized to a ND group or a control diet (CD) group applying an isocaloric study protocol. In this sub-study, we included subjects (n = 89) from three Nordic centers: Kuopio (n =26), Lund (n = 30), and Oulu (n = 33) with a maximum weight change of ±4 kg, high-sensitivity C-reactive protein concentration ≤10 mg L−1, and baseline body mass index <39 kg m−2. PBMCs were isolated, and the mRNA gene expression analysis was measured by quantitative real-time polymerase chain reaction (qPCR). We analyzed the mRNA expression changes of 44 genes before and after a 2hOGTT at the beginning and the end of the intervention. Results: The healthy ND significantly down-regulated the expression of toll-like receptor 4 (TLR4), interleukin 18 (IL18), and thrombospondin receptor (CD36) mRNA transcripts and significantly up-regulated the expression of peroxisome proliferator-activated receptor delta (PPARD) mRNA transcript after the 2hOGTT compared to the CD. Conclusions: A healthy ND is able to modify the gene expression in PBMCs after a 2hOGTT. However, more studies are needed to clarify the biological and clinical relevance of these findings. | language |
dc.language.iso | en | language |
dc.publisher | BioMed Central | language |
dc.relation.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959556/pdf/12263_2016_Article_521.pdf | |
dc.rights | © 2016 Leder et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | language |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Diets | language |
dc.subject | Norway | language |
dc.subject | Metabolic syndrome | language |
dc.subject | mRNA | language |
dc.title | Effects of a healthy Nordic diet on gene expression changes in peripheral blood mononuclear cells in response to an oral glucose tolerance test in subjects with metabolic syndrome: A SYSDIET sub-study | language |
dc.type | Journal article | language |
dc.type | Peer reviewed | language |
dc.date.updated | 2017-05-03T11:23:47Z | |
dc.description.version | publishedVersion | language |
dc.identifier.doi | http://doi.org/10.1186/s12263-016-0521-4 | |
dc.identifier.cristin | 1374214 |
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HV - Institutt for sykepleie og helsefremmende arbeid [1385]
HV - Department of Nursing and Health Promotion
Med mindre annet er angitt, så er denne innførselen lisensiert som © 2016 Leder et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.