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dc.contributor.authorRoman, Martha
dc.contributor.authorCastells, Xavier
dc.contributor.authorHofvind, Solveig
dc.contributor.authorvon Euler-Chelpin, My
dc.date.accessioned2017-05-04T08:31:31Z
dc.date.accessioned2017-05-09T10:27:57Z
dc.date.available2017-05-04T08:31:31Z
dc.date.available2017-05-09T10:27:57Z
dc.date.issued2016
dc.identifier.citationRoman M, Castells X, Hofvind SS, von Euler-Chelpin M. Risk of breast cancer after false-positive results in mammographic screening. Cancer Medicine. 2016;5(6):1298-1306language
dc.identifier.issn2045-7634
dc.identifier.urihttps://hdl.handle.net/10642/4894
dc.description.abstractWomen with false-positive results are commonly referred back to routine screening. Questions remain regarding their long-term outcome of breast cancer. We assessed the risk of screen-detected breast cancer in women with false-positive results. We conducted a joint analysis using individual level data from the population-based screening programs in Copenhagen and Funen in Denmark, Norway, and Spain. Overall, 150,383 screened women from Denmark (1991–2008), 612,138 from Norway (1996–2010), and 1,172,572 from Spain (1990–2006) were included. Poisson regression was used to estimate the relative risk (RR) of screen-detected cancer for women with false-positive versus negative results. We analyzed information from 1,935,093 women 50–69 years who underwent 6,094,515 screening exams. During an average 5.8 years of follow-up, 230,609 (11.9%) women received a false-positive result and 27,849 (1.4%) were diagnosed with screen-detected cancer. The adjusted RR of screen-detected cancer after a false-positive result was 2.01 (95% CI: 1.93–2.09). Women who tested false-positive at first screen had a RR of 1.86 (95% CI: 1.77–1.96), whereas those who tested false-positive at third screening had a RR of 2.42 (95% CI: 2.21–2.64). The RR of breast cancer at the screening test after the false-positive result was 3.95 (95% CI: 3.71–4.21), whereas it decreased to 1.25 (95% CI: 1.17–1.34) three or more screens after the false-positive result. Women with false-positive results had a twofold risk of screen-detected breast cancer compared to women with negative tests. The risk remained significantly higher three or more screens after the false-positive result. The increased risk should be considered when discussing stratified screening strategies.language
dc.language.isoenlanguage
dc.publisherWileylanguage
dc.rights© 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.language
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectMammographylanguage
dc.subjectBreast cancerlanguage
dc.subjectScreening programslanguage
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762language
dc.titleRisk of breast cancer after false-positive results in mammographic screeninglanguage
dc.typeJournal articlelanguage
dc.typePeer reviewedlanguage
dc.date.updated2017-05-04T08:31:31Z
dc.description.versionpublishedVersionlanguage
dc.identifier.doihttp://doi.org/10.1002/cam4.646
dc.identifier.cristin1430945


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© 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.  
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, 
distribution and reproduction in any medium, provided the original work is properly cited.
Med mindre annet er angitt, så er denne innførselen lisensiert som © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.