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dc.contributor.authorMyhrstad, Mari
dc.contributor.authorOttestad, Inger
dc.contributor.authorGünther, Clara-Cecilie
dc.contributor.authorRyeng, Einar
dc.contributor.authorHolden, Marit
dc.contributor.authorNilsson, Astrid
dc.contributor.authorBrønner, Kirsti Wettre
dc.contributor.authorKohler, Achim
dc.contributor.authorBorge, Grethe Iren Andersen
dc.contributor.authorHolven, Kirsten Bjørklund
dc.contributor.authorUlven, Stine Marie
dc.date.accessioned2016-11-16T13:15:23Z
dc.date.accessioned2017-03-27T14:00:20Z
dc.date.available2016-11-16T13:15:23Z
dc.date.available2017-03-27T14:00:20Z
dc.date.issued2016-05-31
dc.identifier.citationGenes & Nutrition 2016, 11:16language
dc.identifier.issn1865-3499
dc.identifier.urihttps://hdl.handle.net/10642/4540
dc.description.abstractBackground: Marine long-chain polyunsaturated fatty acids are susceptible to oxidation, generating a range of different oxidation products with suggested negative health effects. The aim of the present study was to utilize sensitive high-throughput transcriptome analyses to investigate potential unfavorable effects of oxidized fish oil (PV: 18 meq/kg; AV: 9) compared to high-quality fish oil (PV: 4 meq/kg; AV: 3). Methods: In a double-blinded randomized controlled study for seven weeks, 35 healthy subjects were assigned to 8 g of either oxidized fish oil or high quality fish oil. The daily dose of EPA+DHA was 1.6 g. Peripheral blood mononuclear cells were isolated at baseline and after 7 weeks and transcriptome analyses were performed with the illuminaHT-12 v4 Expression BeadChip. Results: No gene transcripts, biological processes, pathway or network were significantly changed in the oxidized fish oil group compared to the fish oil group. Furthermore, gene sets related to oxidative stress and cardiovascular disease were not differently regulated between the groups. Within group analyses revealed a more prominent effect after intake of high quality fish oil as 11 gene transcripts were significantly (FDR < 0.1) changed from baseline versus three within the oxidized fish oil group. Conclusion: The suggested concern linking lipid oxidation products to short-term unfavorable health effects may therefore not be evident at a molecular level in this explorative study. Trial registration: ClinicalTrials.gov, NCT01034423language
dc.language.isoenlanguage
dc.publisherBioMed Centrallanguage
dc.rights© 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.language
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectOxidized fish oillanguage
dc.subjectn-3 fatty acidslanguage
dc.subjectPBMCslanguage
dc.subjectTranscriptomelanguage
dc.subjectHuman interventionlanguage
dc.titleThe PBMC transcriptome profile after intakeof oxidized versus high-quality fish oil: anexplorative study in healthy subjectslanguage
dc.typePeer reviewedlanguage
dc.typeJournal article
dc.date.updated2016-11-16T13:15:23Z
dc.description.versionpublishedVersionlanguage
dc.identifier.doihttp://doi.org/10.1186/s12263-016-0530-6
dc.identifier.cristin1364776
dc.relation.projectIDNofima AS: 3613
dc.relation.projectIDNorges forskningsråd: 225285
dc.relation.projectIDNofima AS: 201304


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© 2016 The Author(s).
Open Access
This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Except where otherwise noted, this item's license is described as © 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.