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dc.contributor.authorSommer, Christine
dc.contributor.authorSletner, Line
dc.contributor.authorMørkrid, Kjersti
dc.contributor.authorJenum, Anne Karen
dc.contributor.authorBirkeland, Kåre Inge
dc.date.accessioned2016-04-22T08:50:47Z
dc.date.available2016-04-22T08:50:47Z
dc.date.issued2015-04-03
dc.identifier.citationSommer, C., Sletner, L., Mørkrid, K., Jenum, A. K., & Birkeland, K. I. (2015). Effects of early pregnancy BMI, mid-gestational weight gain, glucose and lipid levels in pregnancy on offspring’s birth weight and subcutaneous fat: a population-based cohort study. BMC Pregnancy & Childbirth, 15(1), 1.en_US
dc.identifier.issn1471-2393
dc.identifier.otherFRIDAID 1254792
dc.identifier.urihttps://hdl.handle.net/10642/3283
dc.description.abstractBackground: Maternal glucose and lipid levels are associated with neonatal anthropometry of the offspring, also independently of maternal body mass index (BMI). Gestational weight gain, however, is often not accounted for. The objective was to explore whether the effects of maternal glucose and lipid levels on offspring’s birth weight and subcutaneous fat were independent of early pregnancy BMI and mid-gestational weight gain. Methods: In a population-based, multi-ethnic, prospective cohort of 699 women and their offspring, maternal anthropometrics were collected in gestational week 15 and 28. Maternal fasting plasma lipids, fasting and 2-hour glucose post 75 g glucose load, were collected in gestational week 28. Maternal risk factors were standardized using z-scores. Outcomes were neonatal birth weight and sum of skinfolds in four different regions. Results: Mean (standard deviation) birth weight was 3491 ± 498 g and mean sum of skinfolds was 18.2 ± 3.9 mm. Maternal fasting glucose and HDL-cholesterol were predictors of birth weight, and fasting and 2-hour glucose were predictors of neonatal sum of skinfolds, independently of weight gain as well as early pregnancy BMI, gestational week at inclusion, maternal age, parity, smoking status, ethnic origin, gestational age and offspring’s sex. However, weight gain was the strongest independent predictor of both birth weight and neonatal sum of skinfolds, with a 0.21 kg/week increased weight gain giving a 110.7 (95% confidence interval 76.6-144.9) g heavier neonate, and with 0.72 (0.38-1.06) mm larger sum of skinfolds. The effect size of mother’s early pregnancy BMI on birth weight was higher in non-Europeans than in Europeans. Conclusions: Maternal fasting glucose and HDL-cholesterol were predictors of offspring’s birth weight, and fasting and 2-hour glucose were predictors of neonatal sum of skinfolds, independently of weight gain. Mid-gestational weight gain was a stronger predictor of both birth weight and neonatal sum of skinfolds than early pregnancy BMI, maternal glucose and lipid levels.en_US
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.relation.ispartofseriesBMC Pregnancy & Childbirth;15(1)
dc.subjectMaternal glucoseen_US
dc.subjectMaternal lipidsen_US
dc.subjectMid-gestational weight gainen_US
dc.subjectBirth weighten_US
dc.subjectNeonatal adiposityen_US
dc.subjectSubcutaneous faten_US
dc.subjectSkinfoldsen_US
dc.subjectBody compositionen_US
dc.subjectNewbornen_US
dc.subjectMulti-ethnicen_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Sykepleievitenskap: 808en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Andre helsefag: 829en_US
dc.titleEffects of early pregnancy BMI, mid-gestational weight gain, glucose and lipid levels in pregnancy on offspring's birth weight and subcutaneous fat: A population-based cohort studyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.version© 2015 Sommer et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en_US
dc.identifier.doihttp://dx.doi.org/10.1186/s12884-015-0512-5


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