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dc.contributor.authorDomingues, Sara
dc.contributor.authorda Silva, Gabriela Jorge
dc.contributor.authorNielsen, Kaare Magne
dc.date.accessioned2016-04-08T08:46:49Z
dc.date.available2016-07-01T02:03:05Z
dc.date.issued2015-07-01
dc.identifier.citationDomingues, S., da Silva, G. J., & Nielsen, K. M. (2015). Global dissemination patterns of common gene cassette arrays in class 1 integrons. Microbiology, 161(7), 1313-1337.en_US
dc.identifier.issn1350-0872
dc.identifier.otherFRIDAID 1277202
dc.identifier.urihttps://hdl.handle.net/10642/3218
dc.description.abstractIntegrons are genetic elements that contain a site-specific recombination system able to capture, express and exchange gene cassettes. Mobile integrons are widespread and often confer resistance to multiple antibiotics, due to the expression of the arrays of gene cassettes they carry. Although >300 cassette arrays have been described, < 10 array compositions prevail in the reports related to class 1 integrons. These common arrays are found in a broad variety of hosts and environments, highlighting the high level of horizontal dissemination of these elements amongst bacterial populations and species. Clonal expansion also contributes to the current prevalence and inter-regional spread of integron-carrying bacterial species. Here, we review the dissemination pattern of common cassette arrays with a focus on the bacterial species, the geographical dispersal pattern and the environments in which they reside. Conserved arrays of gene cassettes are found in at least 74 countries and 72 species present in different environments. The factors governing the further spread and population dynamics of these cassette arrays remain to be determined.en_US
dc.language.isoengen_US
dc.publisherMicrobiology Societyen_US
dc.relation.ispartofseriesMicrobiology;161(7)
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk mikrobiologi: 715en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk genetikk: 714en_US
dc.subjectDissemination patternsen_US
dc.subjectIntegronsen_US
dc.titleGlobal dissemination patterns of common gene cassette arrays in class 1 integronsen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.identifier.doihttp://dx.doi.org/10.1099/mic.0.000099


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