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dc.contributor.authorSulheim, Dagen_US
dc.contributor.authorFagermoen, Frode Evenen_US
dc.contributor.authorSivertsen, Øyvind Stopleen_US
dc.contributor.authorWinger, Anetteen_US
dc.contributor.authorWyller, Vegard Bruunen_US
dc.contributor.authorØie, Merete Glenneen_US
dc.date.accessioned2016-03-22T08:19:03Z
dc.date.available2016-03-22T08:19:03Z
dc.date.issued2015en_US
dc.identifier.citationSulheim, D., Fagermoen, F.E., Sivertsen, Ø.S., Winger, A., Wyller, V.B. & Øie, M.G. (2015). Cognitive dysfunction in adolescents with chronic fatigue: a cross-sectional study. Archives of Disease in Childhood, 100(9), 838-844. doi: 10.1136/archdischild-2014-306764en_US
dc.identifier.issn0003-9888en_US
dc.identifier.otherFRIDAID 1228070en_US
dc.identifier.urihttps://hdl.handle.net/10642/3165
dc.description.abstractObjective To compare cognitive function in adolescents with chronic fatigue with cognitive function in healthy controls (HC). Study design Cross-sectional study. Setting Paediatric department at Oslo University Hospital, Norway. Participants 120 adolescents with chronic fatigue (average age 15.4 years; range 12–18) and 39 HC (average age 15.2 years; range 12–18). Methods The adolescents completed a neurocognitive test battery measuring processing speed, working memory, cognitive inhibition, cognitive flexibility, verbal learning and verbal memory, and questionnaires addressing demographic data, depression symptoms, anxiety traits, fatigue and sleep problems. Parents completed the Behaviour Rating Inventory of Executive Function (BRIEF), which measures the everyday executive functions of children. Results Adolescents with chronic fatigue had impaired cognitive function compared to HC regarding processing speed (mean difference 3.3, 95% CI 1.1 to 5.5, p=0.003), working memory (−2.4, −3.7 to −1.1, p<0.001), cognitive inhibition response time (6.2, 0.8 to 11.7, p=0.025) and verbal learning (−1.7, −3.2 to −0.3, p=0.022). The BRIEF results indicated that everyday executive functions were significantly worse in the chronic fatigue group compared to the HC (11.2, 8.2 to 14.3, p<0.001). Group differences remained largely unaffected when adjusted for symptoms of depression, anxiety traits and sleep problems. Conclusions Adolescents with chronic fatigue had impaired cognitive function of clinical relevance, measured by objective cognitive tests, in comparison to HC. Working memory and processing speed may represent core difficultiesen_US
dc.language.isoengen_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.ispartofseriesArchives of Disease in Childhood;100(9)en_US
dc.subjectAdolescentsen_US
dc.subjectUngdommeren_US
dc.subjectSchool absenceen_US
dc.subjectFraværen_US
dc.subjectChronic fatigueen_US
dc.subjectUtmattelseen_US
dc.subjectCognitive functionen_US
dc.titleCognitive dysfunction in adolescents with chronic fatigue: a cross-sectional studyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionThis is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
dc.identifier.doihttp://dx.doi.org/10.1136/archdischild-2014-306764


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