• Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin: Educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB) 

      Saenger, Amy K; Jaffe, Allan S.; Body, Richard; Collinson, Paul O.; Kavsak, Peter A.; Lam, Carolyn S. P.; Lefèvre, Guillaume; Omland, Torbjørn; Ordóñez-Llanos, Jordi; Pulkki, Kari; Apple, Fred S. (Clinical Chemistry and Laboratory Medicine (CCLM);57(5), Journal article; Peer reviewed, 2018-06-10)
      Two interferences recently brought to the forefront as patient safety issues include hemolysis (hemoglobin) and biotin (vitamin B7). The International Federation for Clinical Chemistry Committee on Cardiac Biomarkers ...
    • Cardiopulmonary exercise test and PaO2 in evaluation of pulmonary hypertension in COPD 

      Skjørten, Ingunn; Hilde, Janne Mykland; Melsom, Morten Nissen; Hisdal, Jonny; Hansteen, Viggo; Steine, Kjetil; Humerfelt, Sjur (International Journal of Chronic Obstructive Pulmonary Disease;13, Journal article; Peer reviewed, 2017-08-26)
      Background: Exercise tolerance decreases as COPD progresses. Pulmonary hypertension (PH) is common in COPD and may reduce performance further. COPD patients with and without PH could potentially be identified by cardiopulmonary ...
    • Circulating microRNAs as predictive biomarkers of myocardial infarction: Evidence from the HUNT study 

      Velle-Forbord, Torbjørn; Eidlaug, Maria; Debik, Julia Barbara; Sæther, Julia Caroline; Follestad, Turid; Nauman, Javaid; Gigante, Bruna; Røsjø, Helge; Omland, Torbjørn; Langaas, Mette; Bye, Anja (Atherosclerosis;289, Journal article; Peer reviewed, 2019-10)
      Abstract Background and aims Several risk prediction models for coronary heart disease (CHD) are available today, however, they only explain a modest proportion of the incidence. Circulating microRNAs (miRs) have ...
    • Clues for early detection of autoimmune Addison's disease - myths and realities 

      Sævik, Åse Bjorvatn; Akerman, A.-K.; Grønning, Kaja; Nermoen, Ingrid; Valland, Susanna Fonneland; Finnes, Trine Elisabeth; Isaksson, M; Dahlqvist, P; Bergthorsdottir, R; Ekwall, O; Skov, J; Nedrebø, Bjørn Gunnar; Hulting, A.-L.; Wahlberg, J; Svartberg, Johan; Höybye, C; Bleskestad, Inger Hjørdis; Jørgensen, Anders Palmstrøm; Kämpe, Olle; Øksnes, Marianne; Bensing, S; Husebye, Eystein Sverre (Journal of Internal Medicine;283(2), Journal article; Peer reviewed, 2017-11-03)
      BACKGROUND: Early detection of autoimmune Addison's disease (AAD) is important as delay in diagnosis may result in a life-threatening adrenal crisis and death. The classical clinical picture of untreated AAD is well-described, ...
    • Cognitive deficits in chronic stroke patients: neuropsychological assessment, depression, and self-reports 

      Nakling, Arne; Årsland, Dag; Næss, Halvor; Wollschläger, Daniel; Fladby, Tormod; Hofstad, Håkon; Eike, Wehling (Dementia and Geriatric Cognitive Disorders Extra;7(2), Journal article; Peer reviewed, 2017)
      Background: Following stroke, clinicians are challenged to detect and untangle symptoms of cognitive dysfunction and mood disorders. Additionally, they need to evaluate the informative value of self-reports to identify ...
    • Early introduction of oral paricalcitol in renal transplant recipients. An open-label randomized study 

      Pihlstrøm, Hege; Gatti, Francesca; Hammarström, Clara Louise; Eide, Ivar Anders; Kasprzycka, Monika; Wang, Junbai; Haraldsen, Guttorm; Svensson, My Hanna Sofia; Midtvedt, Karsten; Mjøen, Geir; Dahle, Dag Olav; Hartmann, Anders; Holdaas, Hallvard (Transplant International;30(8), Journal article; Peer reviewed, 2017-04-24)
      In stable renal transplant recipients with hyperparathyroidism, previous studies have indicated that vitamin D agonist treatment might have anti-proteinuric effects. Animal studies indicate possible anti-fibrotic and ...
    • Effect of exogenous estrogens and progestogens on the course of migraine during reproductive age: A consensus statement by the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESCRH) 

      Sacco, Simona; Merki-Feld, Gabriele S.; Ægidius, Karen Lehrmann; Bitzer, Johannes; Canonico, Marianne; Gantenbein, Andreas R.; Kurth, Tobias; Lampl, Christian; Lidegaard, Øjvind; MacGregor, Elizabeth Anne; van den Brink, Antoinette Maassen; Mitsikostas, Dimos-Dimitrios; Nappi, Rossella Elena; Ntaios, George; Paemeleire, Koen; Sandset, Per Morten; Terwindt, Gisela Marie; Vetvik, Kjersti; Martelletti, Paolo (The journal of headache and pain;19(1), Journal article; Peer reviewed, 2018-08-31)
      We systematically reviewed data about the effect of exogenous estrogens and progestogens on the course of migraine during reproductive age. Thereafter a consensus procedure among international experts was undertaken to ...
    • Efficacy of response-guided directly observed pegylated interferon and self-administered ribavirin for people who inject drugs with hepatitis C virus genotype 2/3 infection: The ACTIVATE study 

      Grebely, Jason; Dalgard, Olav; Cunningham, Evan B; Hajarizadeh, Behzad; Foster, Graham R; Bruggmann, Philip; Conway, Brian; Backmund, Markus; Robaeys, Geert; Swan, Tracy; Amin, Janaki; Marks, Philippa S; Quiene, Sophie; Applegate, Tanya L; Weltman, Martin; Shaw, David; Dunlop, Adrian; Hellard, Margaret; Bruneau, Julie; Midgard, Håvard; Bourgeois, Stefan; Staehelin, Cornelia; Dore, Gregory J (International Journal of Drug Policy;47, Journal article; Peer reviewed, 2017-09)
      Background There are few data on treatment for hepatitis C virus (HCV) infection among people with ongoing injecting drug use. This study evaluated the efficacy of response-guided therapy for chronic HCV genotypes 2/3 ...
    • Extending XNAT platform with an incremental semantic framework 

      Reina, Santiago Timon; Rincón, Mariano; Martinez-Tomás, Rafael (Frontiers in Neuroinformatics;11, Journal article; Peer reviewed, 2017-08-31)
      Informatics increases the yield from neuroscience due to improved data. Data sharing and accessibility enable joint efforts between different research groups, as well as replication studies, pivotal for progress in the ...
    • Fatigue is not associated with vitamin D deficiency in inflammatory bowel disease patients 

      Frigstad, Svein Oskar; Høivik, Marte Lie; Jahnsen, Jørgen; Småstuen, Milada Cvancarova; Grimstad, Tore; Berset, Ingrid Prytz; Huppertz-Hauss, Gert; Hovde, Øistein; Bernklev, Tomm; Moum, Bjørn; Jelsness-Jørgensen, Lars-Petter (World journal of gastroenterology;24(29), Journal article; Peer reviewed, 2018-08-07)
      AIM To investigate if vitamin D deficiency is associated with fatigue in patients with inflammatory bowel disease (IBD). METHODS IBD patients were recruited from nine hospitals in the southeastern and western regions ...
    • Finasteride treatment and male breast cancer: a register-based cohort study in four Nordic countries 

      Meijer, Mathias; Thygesen, Lau Caspar; Green, Anders; Emneus, Martha; Brasso, Klaus; Iversen, Peter; Pukkalo, Eero; Bolin, Kristian; Stavem, Knut; Ersbøll, Annette Kjær (Cancer medicine;7(1), Journal article; Peer reviewed, 2017-12-13)
      A potential link has been suggested between dispensed finasteride and increased risk of male breast cancer (MBC). Due to the rare occurrence of MBC, it remains to be established if such a relationship exists. The purpose ...
    • Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study 

      Blach, Sarah; Zeuzem, Stefan; Manns, Michael; Altraif, Ibrahim; Duberg, Ann-Sofi; Muljono, David H; Waked, Imam; Alavian, Seyed M; Lee, Mei-Hsuan; Negro, Francesco; Abaalkhail, Faisal; Abdou, Ahmed; Abdulla, Maheeba; Rached, Antoine Abou; Aho, Inka; Akarca, Ulus; Ghazzawi, Imad Al; Kaabi, Saad Al; Lawati, Faryal Al; Namaani, Khalid Al; Serkal, Youssif Al; Al-Busafi, Said A; Al-Dabal, Layla; Aleman, Soo; Alghamdi, Abdullah S; Aljumah, Abdulrahman A; Al-Romaihi, Hamad E; Andersson, Monique I; Arendt, Vic; Arkkila, Perttu; Assiri, Abdullah M; Baatarkhuu, Oidov; Bane, Abate; Ben-Ari, Ziv; Bergin, Colm; Bessone, Fernando; Bihl, Florian; Bizri, Abdul R; Blachier, Martin; Blasco, Antonio J; Mello, Carlos E Brandao; Bruggmann, Philip; Brunton, Cheryl R; Calinas, Filipe; Chan, Henry L Y; Chaudhry, Asad; Cheinquer, Hugo; Chen, Chien-Jen; Chien, Rong-Nan; Choi, Moon Seok; Christensen, Peer B; Chuang, Wan-Long; Chulanov, Vladimir; Cisneros, Laura; Clausen, Mette R; Cramp, Matthew E; Craxi, Antonio; Croes, Esther A; Dalgard, Olav (The Lancet Gastroenterology and Hepatology;2(3), Journal article; Peer reviewed, 2017-03)
      Background The 69th World Health Assembly approved the Global Health Sector Strategy to eliminate hepatitis C virus (HCV) infection by 2030, which can become a reality with the recent launch of direct acting antiviral ...
    • Health status in subjects with suspected obstructive sleep apnea and comparison with a general population 

      Beiske, Kornelia Katalin; Stavem, Knut (Scientific reports;8(1), Journal article; Peer reviewed, 2018-04-03)
      The purpose of this study was to assess health status (HS) in patients with clinical suspicion of obstructive sleep apnea (OSA) in order to estimate the dose response relationship between HS and OSA severity, and to ...
    • Impaired synaptic function is linked to cognition in Parkinson's disease 

      Selnes, Per; Stav, Ane Løvli; Johansen, Krisztina Kunszt; Bjørnerud, Atle; Coello, Sebastien Christopher; Auning, Eirik; Kalheim, Lisa Flem; Almdahl, Ina Selseth; Hessen, Erik; Zetterberg, Henrik; Blennow, Kaj; Årsland, Dag; Fladby, Tormod (Annals of Clinical and Translational Neurology;4(10), Journal article; Peer reviewed, 2017-08-31)
      Objective Cognitive impairment is frequent in Parkinson's disease, but the underlying mechanisms are insufficiently understood. Because cortical metabolism is reduced in Parkinson's disease and closely associated with ...
    • Inflammation and Mechanical Stress Stimulate Osteogenic Differentiation of Human Aortic Valve Interstitial Cells 

      Bogdanova, Mariia; Kostina, Aleksandra; Zihlavnikova, Katarina; Zabirnyk, Arsenii; Malashicheva, Anna; Stensløkken, Kåre-Olav; Sullivan, Gareth; Kaljusto, Mari-Liis; Kvitting, John Peder Escobar; Kostareva, Anna; Vaage, Ingvar Jarle; Rutkovskiy, Arkady (Frontiers in physiology;9, Journal article; Peer reviewed, 2018-11-20)
      Background: Aortic valve calcification is an active proliferative process, where interstitial cells of the valve transform into either myofibroblasts or osteoblast-like cells causing valve deformation, thickening of cusps ...
    • Left ventricular biomechanics in professional football players 

      von Lueder, Thomas Gero; Hodt, Anders; Gjerdalen, Gard Filip; Steine, Kjetil (Scandinavian journal of medicine & science in sports;28(1), Journal article; Peer reviewed, 2017-04-04)
      Chronic exercise induces adaptive changes of left ventricular (LV) ejection and filling capacities which may be detected by novel speckle‐tracking echocardiography (STE) and tissue Doppler imaging (TDI)‐based techniques. ...
    • Morbidity outcomes after surgical aortic valve replacement 

      Auensen, Andreas; Hussain, Amjad Iqbal; Bendz, Bjørn; Aaberge, Lars; Falk, Ragnhild Sørum; Hansen, Marte; Bye, Eva; Andreassen, Johanna; Beitnes, Jan Otto; Rein, Kjell Arne; Pettersen, Kjell I; Gullestad, Lars (Open Heart;4(1), Journal article; Peer reviewed, 2017-04-13)
      Objective In patients with mild to moderate operative risk, surgical aortic valve replacement (SAVR) is still the preferred treatment for patients with severe symptomatic aortic stenosis (AS). Aiming to broaden the knowledge ...
    • NAD+ in aging: molecular mechanisms and translational implications 

      Fang, Evandro Fei; Lautrup, Sofie; Hou, Yujun; Demarest, Tyler G; Croteau, Deborah L; Mattson, Mark P; Bohr, Vilhelm A (Trends in Molecular Medicine;23/10, Journal article; Peer reviewed, 2017-10)
      AB The coenzyme NAD+ is critical in cellular bioenergetics and adaptive stress responses. Its depletion has emerged as a fundamental feature of aging that may predispose to a wide range of chronic diseases. Maintenance of ...
    • Novel biomarkers of cardiovascular disease: Applications in clinical practice 

      Lyngbakken, Magnus; Myhre, Peder Langeland; Røsjø, Helge; Omland, Torbjørn (Critical reviews in clinical laboratory sciences;56(1), Journal article; Peer reviewed, 2018-11-20)
      Measurement of biomarkers has revolutionized the work-up of patients with suspected cardiovascular disease. The most widely used contemporary cardiovascular biomarkers are the natriuretic peptides in the diagnosis and ...
    • Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis 

      Vesterhus, Mette; Holm, Anders; Hov, Johannes Espolin Roksund; Nygård, Ståle; Schrumpf, Erik; Melum, Espen; Thorbjørnsen, Liv Wenche; Paulsen, Vemund; Lundin, Knut Erik Aslaksen; Dale, Inge; Gilja, Odd Helge; Zweers, Serge J.; Vatn, Morten H.; Schaap, Frank G.; Jansen, Peter L. M.; Ueland, Thor; Røsjø, Helge; Moum, Bjørn; Ponsioen, Cyriel Y.; Boberg, Kirsten Muri; Färkkilä, Martti; Karlsen, Tom Hemming; Lund-Johansen, Fridtjof (Journal of hepatology;66(6), Journal article; Peer reviewed, 2017-02-02)
      Background & Aims Prognostic biomarkers are lacking in primary sclerosing cholangitis, hampering patient care and the development of therapy. We aimed to identify novel protein biomarkers of disease severity and prognosis ...