• Sofosbuvir based treatment of chronic hepatitis C genotype 3 infections - a Scandinavian real-life study 

      Dalgard, Olav; Weiland, Ola; Noraberg, Geir; Karlsen, Lars Normann; Heggelund, Lars; Färkkilä, Martti; Balselv, Ulla; Berlard, Erika; Øvrehus, Anne; Kjær, Mette Skalshøi; Krarup, Henrik; Røge, Birgit Thorup; Hallager, Sofie; Madsen, Lone G; Laursen, Alex Lund; Lagging, Martin; Weis, Nina (PLoS ONE;12(7), Journal article; Peer reviewed, 2017-07-13)
      Background and aims Chronic hepatitis C virus (HCV) genotype 3 infection with advanced liver disease has emerged as the most challenging to treat. We retrospectively assessed the treatment outcome of sofosbuvir (SOF) based ...
    • The usage of fasting glucose and glycated hemoglobin for the identification of unknown type 2 diabetes in high risk patients with morbid obesity 

      Valderhaug, Tone Gretland; Sharma, Archana; Kravdal, Gunnhild; Rønningen, Reidun; Nermoen, Ingrid (Scandinavian journal of clinical and laboratory investigation;77(7), Journal article; Peer reviewed, 2017-07-17)
      Background: In spite of increased vigilance of undiagnosed type 2 diabetes (DM2), the prevalence of unknown DM2 in subjects with morbid obesity is not known. Aim: To assess the prevalence of undiagnosed DM2 and compare ...
    • Factors associated with life-sustaining treatment restriction in a general intensive care unit 

      Skjaker, Stein Arve; Hoel, Henrik; Dahl, Vegard; Stavem, Knut (PloS one;12(7), Journal article; Peer reviewed, 2017-07-18)
      Abstract Purpose Few previous studies have investigated associations between clinical variables available after 24 hours in the intensive care unit (ICU), including the Charlson Comorbidity Index (CCI), and decisions to ...
    • No associations established between single nucleotide polymorphisms in human Toll-like receptor 2 and Toll-interacting protein and Staphylococcus aureus bloodstream infections 

      Smeland, Tor Eirik; Müller, Fredrik; Blomfeldt, Anita; Stavem, Knut; Aamot, Hege Vangstein (Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS);125(10), Journal article; Peer reviewed, 2017-07-24)
      Staphylococcus aureus bloodstream infections (SABSI) are associated with high morbidity and mortality. The Toll‐like receptor 2 (TLR2) and Toll‐interacting protein (TOLLIP) are important in recognition and regulation of ...
    • Biomarkers in subtypes of mild cognitive impairment and subjective cognitive decline 

      Eliassen, Carl F Andestad; Reinvang, Ivar; Selnes, Per; Grambaite, Ramune; Fladby, Tormod; Hessen, Erik (Brain and Behavior;7(9), Journal article; Peer reviewed, 2017-07-28)
      Objectives Preclinical Alzheimers disease (AD) patients may or may not show cognitive impairment on testing. AD biomarkers are central to the identification of those at low, intermediate, or high risk of later dementia ...
    • In vitro biological validation and cytocompatibility evaluation of hydrogel iron-oxide nanoparticles 

      Catalano, Enrico (AIP Conference Proceedings;1873, Journal article; Peer reviewed, 2017-08-02)
      Superparamagnetic iron oxide nanoparticles (MNPs) have recently been investigated for their excellent biocompatibility as well as multi-purpose biomedical potential with promising results, owing to their ability to be ...
    • A national, prospective observational study of first recurrence after primary treatment for gynecological cancer in Norway 

      Vistad, Ingvild; Bjørge, Line; Popova, Olesya; Fiane, Bent; Sachse, Kurt; Tjugum, Ivar Jostein; Skrøppa, Siri; Bentzen, Anne Gry; Stokstad, Trine; Iversen, Grete Alræk; Salvesen, Helga Birgitte; Kristensen, Gunnar S Balle; Dørum, Anne (Acta Obstetricia et Gynecologica Scandinavica;96(10), Journal article; Peer reviewed, 2017-08-10)
      INTRODUCTION: Gynecological cancer patients are routinely followed up for five years after primary treatment. However, the value of such follow up has been debated, as retrospective studies indicate that first recurrence ...
    • An international investigation into O red blood cell unit administration in hospitals: the GRoup O Utilization Patterns (GROUP) study 

      Zeller, Michelle P.; Barty, Rebecca; Aandahl, Astrid; Apelseth, Torunn Oveland; Callum, Jeannie; Dunbar, Nancy M.; Elahie, Allahna; Garritsen, Henk; Hancock, Helen; Kutner, José Mauro; Manukian, Belinda; Mizuta, Shuichi; Okuda, Makoto; Pagano, Monica B.; Pogłód, Ryszard; Rushford, Kylie; Selleng, Kathleen; Sørensen, Claess Henning; Sprogøe, Ulrik; Staves, Julie; Weiland, Thorsten; Wendel, Silvano; Wood, Erica M.; Watering, Leo van de; Wordragen-Vlaswinkel, Maria van; Ziman, Alyssa; Zwaginga, Jaap Jan; Murphy, Michael F.; Heddle, Nancy M.; Yazer, Mark H. (Transfusion;57(10), Journal article; Peer reviewed, 2017-08-25)
      BACKGROUND: Transfusion of group O blood to non-O recipients, or transfusion of D- blood to D+ recipients, can result in shortages of group O or D- blood, respectively. This study investigated RBC utilization patterns at ...
    • Cardiopulmonary exercise test and PaO2 in evaluation of pulmonary hypertension in COPD 

      Skjørten, Ingunn; Hilde, Janne Mykland; Melsom, Morten Nissen; Hisdal, Jonny; Hansteen, Viggo; Steine, Kjetil; Humerfelt, Sjur (International Journal of Chronic Obstructive Pulmonary Disease;13, Journal article; Peer reviewed, 2017-08-26)
      Background: Exercise tolerance decreases as COPD progresses. Pulmonary hypertension (PH) is common in COPD and may reduce performance further. COPD patients with and without PH could potentially be identified by cardiopulmonary ...
    • Predictive value of C-reactive protein in patients treated with sunitinib for metastatic clear cell renal cell carcinoma 

      Pilskog, Martin; Beisland, Christian; Akslen, Lars A; Bostad, Leif; Haug, Åse; Heinrich, Daniel; Hjelle, Karin Margrethe; Straume, Oddbjørn (BMC Urology;17(1), Journal article; Peer reviewed, 2017-08-31)
      Background Sunitinib has become mainstay first line treatment for patients with metastatic renal clear cell carcinoma (mRCC). Still, useful predictive markers of response are lacking and urgently needed for clinical ...
    • Extending XNAT platform with an incremental semantic framework 

      Reina, Santiago Timon; Rincón, Mariano; Martinez-Tomás, Rafael (Frontiers in Neuroinformatics;11, Journal article; Peer reviewed, 2017-08-31)
      Informatics increases the yield from neuroscience due to improved data. Data sharing and accessibility enable joint efforts between different research groups, as well as replication studies, pivotal for progress in the ...
    • Impaired synaptic function is linked to cognition in Parkinson's disease 

      Selnes, Per; Stav, Ane Løvli; Johansen, Krisztina Kunszt; Bjørnerud, Atle; Coello, Sebastien Christopher; Auning, Eirik; Kalheim, Lisa Flem; Almdahl, Ina Selseth; Hessen, Erik; Zetterberg, Henrik; Blennow, Kaj; Årsland, Dag; Fladby, Tormod (Annals of Clinical and Translational Neurology;4(10), Journal article; Peer reviewed, 2017-08-31)
      Objective Cognitive impairment is frequent in Parkinson's disease, but the underlying mechanisms are insufficiently understood. Because cortical metabolism is reduced in Parkinson's disease and closely associated with ...
    • Research priorities to achieve universal access to hepatitis C prevention, management and direct-acting antiviral treatment among people who inject drugs. 

      Grebely, Jason; Bruneau, Julie; Lazarus, Jeffrey; Dalgard, Olav; Bruggmann, Philip; Treloar, Carla; Hickman, Matthew; Hellard, Margaret; Roberts, Teri; Crooks, Levinia; Midgard, Håvard; Larney, Sarah; Degenhardt, Louisa; Alho, Hannu; Byrne, Jude; Dillon, John F; Feld, Jordan J; Foster, Graham; Goldberg, David E; Lloyd, Andrew R; Reimer, Jens; Robaeys, Geert; Torrens, Marta; Wright, Nat; Maremmani, Icro; Norton, Brianna L; Litwin, Alain H; Dore, Gregory J (International Journal of Drug Policy;47, Journal article; Peer reviewed, 2017-09)
      Globally, it is estimated that 71.1 million people have chronic hepatitis C virus (HCV) infection, including an estimated 7.5 million people who have recently injected drugs (PWID). There is an additional large, but ...
    • Efficacy of response-guided directly observed pegylated interferon and self-administered ribavirin for people who inject drugs with hepatitis C virus genotype 2/3 infection: The ACTIVATE study 

      Grebely, Jason; Dalgard, Olav; Cunningham, Evan B; Hajarizadeh, Behzad; Foster, Graham R; Bruggmann, Philip; Conway, Brian; Backmund, Markus; Robaeys, Geert; Swan, Tracy; Amin, Janaki; Marks, Philippa S; Quiene, Sophie; Applegate, Tanya L; Weltman, Martin; Shaw, David; Dunlop, Adrian; Hellard, Margaret; Bruneau, Julie; Midgard, Håvard; Bourgeois, Stefan; Staehelin, Cornelia; Dore, Gregory J (International Journal of Drug Policy;47, Journal article; Peer reviewed, 2017-09)
      Background There are few data on treatment for hepatitis C virus (HCV) infection among people with ongoing injecting drug use. This study evaluated the efficacy of response-guided therapy for chronic HCV genotypes 2/3 ...
    • A survey of the clinicopathological and molecular characteristics of patients with suspected Lynch syndrome in Latin America 

      Rossi, Benedito Mauro; Palmero, Edenir Inêz; López-Kostner, Francisco; Sarroca, Carlos; Vaccaro, Carlos Alberto; Spirandelli, Florencia; Ashton-Prolla, Patricia; Rodriguez, Yenni; Galvão, Henrique de Campos Reis; Reis, Rui Manuel; dePaula, André Escremim; Romagnolo, Luis Gustavo Capochin; Alvarez, Karin; Valle, Adriana Della; Neffa, Florencia; Kalfayan, Pablo German; Spirandelli, Enrique; Chialina, Sergio; Angulo, Melva Gutiérrez; Castro-Mujica, Maria del Carmen; de Monte, Julio Sanchez; Quispe, Richard; de Silva, Sabrina Daniela; Rossi, Norma Teresa; Barletta-Carrillo, Claudia; Revollo, Susann; Taborga, Ximena; Morillas, L. Lena; Tubeuf, Hélène; Monteiro-Santos, Erika Maria; Piñero, Tamara Alejandra; Dominguez-Barrera, Constantino; Wernhoff, Patrik; Martins, Alexandra; Hovig, Eivind; Møller, Pål; Valentin, Mev Dominguez (BMC cancer;17(1), Journal article; Peer reviewed, 2017-09-05)
      Background Genetic counselling and testing for Lynch syndrome (LS) have recently been introduced in several Latin America countries. We aimed to characterize the clinical, molecular and mismatch repair (MMR) variants ...
    • Bone turnover markers are associated with bone density, but not with fracture in end stage kidney disease: a cross-sectional study 

      Jørgensen, Hanne Skou; Winther, Simon; Bøttcher, Morten; Hauge, Ellen Margrethe; Rejnmark, Lars; Svensson, My Hanna Sofie; Ivarsen, Per (BMC Nephrology;18(1), Journal article; Peer reviewed, 2017-09-06)
      Background Fracture risk is increased in chronic kidney disease (CKD), but assessment of bone fragility remains controversial in these patients. This study investigated the associations between bone turnover markers, bone ...
    • An update on cladribine for relapsing-remitting multiple sclerosis 

      Holmøy, Trygve; Torkildsen, Øivind Fredvik; Myhr, Kjell-Morten (Expert Opinion on Pharmacotherapy;18(15), Journal article; Peer reviewed, 2017-09-11)
      INTRODUCTION: Despite recent progress, currently available therapies for relapsing remitting multiple sclerosis (MS) are only partly effective, and their use is limited by tolerability and safety issues, as well as high ...
    • Community treatment orders and social outcomes for patients with psychosis: a 48-month follow-up study 

      Vergunst, Francis; Rugkåsa, Jorun; Koshiaris, Constantinos; Simon, Judit; Burns, Tom (Social Psychiatry and Psychiatric Epidemiology;52(11), Journal article; Peer reviewed, 2017-09-12)
      PURPOSE: Community treatment orders (CTOs) are widely used internationally despite a lack of evidence supporting their effectiveness. Most effectiveness studies are relatively short (12-months or less) and focus on clinical ...
    • Ankylosing Spondylitis and Axial Spondyloarthritis in Patients With Long-term Inflammatory Bowel Disease: Results From 20 Years of Follow-up in the IBSEN Study 

      Ossum, Alvilde Maria; Palm, Øyvind; Lunder, Aida Kapic; Småstuen, Milada Cvancarova; Banitalebi, Hasan; Negård, Anne; Høie, Ole Ingebreth; Henriksen, Magne; Moum, Bjørn; Høivik, Marte Lie (Journal of Crohn's and Colitis;12(1), Journal article; Peer reviewed, 2017-09-13)
      Background Patients with inflammatory bowel disease [IBD] often suffer from rheumatic manifestations, including inflammatory back disorders. The prevalence of these disorders late in the course of IBD is poorly investigated. ...
    • Prevalence of posttraumatic stress disorder in persons with chronic pain: A meta-analysis 

      Siqveland, Johan; Hussain, Ajmal; Lindstrøm, Jonas Christoffer; Ruud, Torleif; Hauff, Edvard (Frontiers in Psychiatry;8, Journal article; Peer reviewed, 2017-09-14)
      Objective: To summarize evidence for the prevalence of posttraumatic stress disorder (PTSD) among persons with chronic pain (CP). Methods: We searched databases for studies published between January 1995 and December ...