• Predictive value of C-reactive protein in patients treated with sunitinib for metastatic clear cell renal cell carcinoma 

      Pilskog, Martin; Beisland, Christian; Akslen, Lars A; Bostad, Leif; Haug, Åse; Heinrich, Daniel; Hjelle, Karin Margrethe; Straume, Oddbjørn (BMC Urology;17(1), Journal article; Peer reviewed, 2017-08-31)
      Background Sunitinib has become mainstay first line treatment for patients with metastatic renal clear cell carcinoma (mRCC). Still, useful predictive markers of response are lacking and urgently needed for clinical ...
    • Preserved endothelial function in young adults with type 1 diabetes 

      Heier, Martin; Espeland, Cathrine Nygaard; Brunborg, Cathrine; Seljeflot, Ingebjørg; Margeirsdottir, Hanna Dis; Hanssen, Kristian Folkvord; Fugleseth, Drude Merete; Dahl-Jørgensen, Knut (PLoS ONE;13(10), Journal article; Peer reviewed, 2018-10-25)
      Background and aim Endothelial dysfunction is involved in the pathogenesis of atherosclerosis and is typically present in older adults with type 1 diabetes (T1D). In young adults, we aimed to assess the impact of T1D on ...
    • Prevalence of carotid plaque in a 63- to 65-Year-Old Norwegian cohort from the general population: The ACE (Akershus Cardiac Examination) 1950 study 

      Ihle-Hansen, Håkon; Vigen, Thea; Ihle-Hansen, Hege; Rønning, Ole M.; Berge, Trygve; Thommessen, Bente; Lyngbakken, Magnus; Orstad, Eivind Bjørkan; Enger, Steve; Nygård, Ståle; Røsjø, Helge; Tveit, Arnljot (Journal of the American Heart Association;7(10), Journal article; Peer reviewed, 2018-05-08)
      Background New data on extracranial carotid atherosclerosis are needed, as improved ultrasound techniques may detect more atherosclerosis, the definition of plaque has changed over the years, and better cardiovascular ...
    • Prevalence of posttraumatic stress disorder in persons with chronic pain: A meta-analysis 

      Siqveland, Johan; Hussain, Ajmal; Lindstrøm, Jonas Christoffer; Ruud, Torleif; Hauff, Edvard (Frontiers in Psychiatry;8, Journal article; Peer reviewed, 2017-09-14)
      Objective: To summarize evidence for the prevalence of posttraumatic stress disorder (PTSD) among persons with chronic pain (CP). Methods: We searched databases for studies published between January 1995 and December ...
    • Prognostic factors for long-term outcome of chronic slipped capital femoral epiphysis treated with fixation in situ 

      Terjesen, Terje; Wensaas, Anders (Journal of Children's Orthopaedics;11(2), Journal article; Peer reviewed, 2017-04-06)
      Purpose Predictive factors for long-term outcome after in situ fixation for chronic slipped capital femoral epiphysis (SCFE) have so far not been systematically analysed. The aims of this study were to define predictors ...
    • A prospective, quantitative study of mental health act assessments in England following the 2007 amendments to the 1983 act: Did the changes fulfill their promise? 

      Singh, Swaran P; Paul, Moli; Parsons, Helen; Burns, Tom; Pyrer, Peter; Fazel, Seena; Deb, Shoumitro; Islam, Zoebia; Rugkåsa, Jorun; Gajwani, Ruchika; Thana, Lavanya; Crawford, Michael J (BMC psychiatry;17(1), Journal article; Peer reviewed, 2017-07-10)
      Background In 2008, the Mental Health Act (MHA) 2007 amendments to the MHA 1983 were implemented in England and Wales. The amendments were intended to remove perceived obstacles to the detention of high risk patients with ...
    • The psychometric properties of the 'safety Attitudes questionnaire' in out-of-hours primary care services in the Netherlands 

      Smits, Marleen; Keizer, Ellen; Giesen, Paul; Deilkås, Ellen C Tveter; Hofoss, Dag; Bondevik, Gunnar Tschudi (PloS ONE;12(2), Journal article; Peer reviewed, 2017-02-16)
      Background The Safety Attitudes Questionnaire (SAQ) is one of the most widely used instruments to assess safety culture among healthcare providers. The ambulatory version of the SAQ (SAQ-AV) can be used in the primary ...
    • Pulseless electrical activity: A misdiagnosed entity during asphyxia in newborn infants? 

      Patel, Sparsh; Cheung, Po-Yin; Solevåg, Anne Lee; Barrington, Keith J; Kamlin, C. Omar Farouk; Davis, Peter G.; Schmölzer, Georg Marcus (Archives of Disease in Childhood-Fetal and Neonatal Edition;104(2), Journal article; Peer reviewed, 2018-06-12)
      Background The 2015 neonatal resuscitation guidelines added ECG as a recommended method of assessment of an infant’s heart rate (HR) when determining the need for resuscitation at birth. However, a recent case report raised ...
    • Rat model of chronic tympanic membrane perforation: A longitudinal histological evaluation of underlying mechanisms 

      Wang, Allen Y; Liew, Lawrence J; Shen, Yi; Wang, Jeffrey T; Unge, Magnus Von; Atlas, Marcus D; Dilley, Rodney J (International Journal of Pediatric Otorhinolaryngology;93, Journal article; Peer reviewed, 2017-02)
      Objective To evaluate histologically the progressive development and underlying mechanisms of chronic tympanic membrane perforation (TMP) in a rat model using a two-weeks ventilation tube (VT) treatment combined with ...
    • Research priorities to achieve universal access to hepatitis C prevention, management and direct-acting antiviral treatment among people who inject drugs. 

      Grebely, Jason; Bruneau, Julie; Lazarus, Jeffrey; Dalgard, Olav; Bruggmann, Philip; Treloar, Carla; Hickman, Matthew; Hellard, Margaret; Roberts, Teri; Crooks, Levinia; Midgard, Håvard; Larney, Sarah; Degenhardt, Louisa; Alho, Hannu; Byrne, Jude; Dillon, John F; Feld, Jordan J; Foster, Graham; Goldberg, David E; Lloyd, Andrew R; Reimer, Jens; Robaeys, Geert; Torrens, Marta; Wright, Nat; Maremmani, Icro; Norton, Brianna L; Litwin, Alain H; Dore, Gregory J (International Journal of Drug Policy;47, Journal article; Peer reviewed, 2017-09)
      Globally, it is estimated that 71.1 million people have chronic hepatitis C virus (HCV) infection, including an estimated 7.5 million people who have recently injected drugs (PWID). There is an additional large, but ...
    • Respiratory pump maintains cardiac stroke volume during hypovolemia in young, healthy volunteers 

      Skytioti, Maria; Søvik, Signe; Elstad, Maja (Journal of Applied Physiology;124(5), Journal article; Peer reviewed, 2018-05-24)
      Abstract Spontaneous breathing has beneficial effects on the circulation, since negative intrathoracic pressure enhances venous return and increases cardiac stroke volume. We quantified the contribution of the respiratory ...
    • A review of oxygen use during chest compressions in Newborns-A meta-analysis of animal data 

      Garcia-Hidalgo, Catalina; Cheung, Po-Yin; Vento, Máximo; O´Reilly, Megan; Saugstad, Ola Didrik; Schmölzer, Georg M. (Frontiers in pediatrics;6, Journal article; Peer reviewed, 2018-12-18)
      Background: International consensus statements for resuscitation of newborn infants recommend provision of 100% oxygen once chest compressions are required. However, 100% oxygen exacerbates reperfusion injury and reduces ...
    • Right and left ventricular function in hospitalized children with respiratory syncytial virus infection 

      Horter, Thorsten; Nakstad, Britt; Ashtari, Omid; Solevåg, Anne Lee (Infection and Drug Resistance;10, Journal article; Peer reviewed, 2017-11-07)
      Background: Extrapulmonary manifestations including cardiac dysfunction have been demonstrated in children with respiratory syncytial virus (RSV) infection requiring intensive care. The aim of this study was to examine ...
    • Safe surgery checklist, patient safety, teamwork and responsibility - coequal demands? A Focus Group study 

      Willassen, Elin Thove; Jacobsen, Inger Lise Smith; Tveiten, Sidsel (Global qualitative nursing research;5, Journal article; Peer reviewed, 2018-03-28)
      The use of World Health Organization’s (WHO’s) Safe Surgery checklist is an established practice worldwide and contributes toward ensuring patient safety and collaborative teamwork. The aim of this study was to elucidate ...
    • The safety attitudes questionnaire - ambulatory version: psychometric properties of the Slovenian version for the out-of-hours primary care setting 

      Klemenc-Ketis, Zalika; Maletic, Matjaz; Stropnik, Vesna; Deilkås, Ellen C Tveter; Hofoss, Dag; Bondevik, Gunnar Tchudi (BMC Health Services Research;17(1), Journal article; Peer reviewed, 2017-01-13)
      Background Several tools have been developed to measure safety attitudes of health care providers, out of which the Safety Attitudes Questionnaire (SAQ) is regarded as one of the most appropriate ones. In 2007, it was ...
    • Searching for ‘transformative moments’: a qualitative study of nurses’ work during home visits to COPD patients and their caregivers in Norway 

      Aasbø, Gunvor; Kristvik, Ellen Elisabeth; Solbrække, Kari Nyheim; Werner, Anne (Nursing Open;6(2), Journal article; Peer reviewed, 2018-10-09)
      Aim The integration of families into healthcare services is being emphasized increasingly in healthcare polices. The aim of this study was to investigate how professionals during home visits support both patients and ...
    • Serum cytokine levels in breast cancer patients during neoadjuvant treatment with bevacizumab 

      Jabeen, Shakila; Zucknick, Karola Manuela; Nome, Marianne Eikhom; Dannenfelser, Ruth; Fleischer, Thomas; Kumar, Surendra; Luders, Torben; Gythfeldt, Hedda; Troyanskya, Olga; Kyte, Jon A.; Børresen-Dale, Anne-Lise; Naume, Bjørn; Tekpli, Xavier; Engebråten, Olav; Kristensen, Vessela N. (Oncoimmunology;7(11), Journal article; Peer reviewed, 2018-01-08)
      A high concentration of circulating vascular endothelial growth factor (VEGF) in cancer patients is associated with an aggressive tumor phenotype. Here, serum levels of 27 cytokines and blood cell counts were assessed in ...
    • Sofosbuvir and velpatasvir for hepatitis C virus infection in people with recent injection drug use (SIMPLIFY): an open-label, single-arm, phase 4, multicentre trial 

      Grebely, Jason; Dalgard, Olav; Conway, Brian; Cunningham, Evan B.; Bruggmann, Philip; Hajarizadeh, Behzad; Amin, Janaki; Bruneau, Julie; Hellard, Margaret; Litwin, Alain H.; Marks, Phillippa; Quiene, Sophie; Siriragavan, Sharmila; Applegate, Tanya L.; Swan, Tracy; Byrne, Jude; Lacalamita, Melanie; Dunlop, Adrian; Matthews, Gail V.; Powis, Jeff; Shaw, David; Thurnheer, Maria Christine; Weltmann, Martin; Kronborg, Ian; Cooper, Curtis; Feld, Jordan J.; Fraser, Chris; Dillon, John F.; Read, Phillip; Gane, Edward; Dore, Gregory J. (The lancet Gastroenterology & hepatology;3(3), Journal article; Peer reviewed, 2018-03)
      Background Despite revised guidelines that no longer exclude people who inject drugs (PWID) from treatment for hepatitis C virus (HCV) infection, many clinicians are reluctant to treat recent PWID. This study aimed to ...
    • Sofosbuvir based treatment of chronic hepatitis C genotype 3 infections - a Scandinavian real-life study 

      Dalgard, Olav; Weiland, Ola; Noraberg, Geir; Karlsen, Lars Normann; Heggelund, Lars; Färkkilä, Martti; Balselv, Ulla; Berlard, Erika; Øvrehus, Anne; Kjær, Mette Skalshøi; Krarup, Henrik; Røge, Birgit Thorup; Hallager, Sofie; Madsen, Lone G; Laursen, Alex Lund; Lagging, Martin; Weis, Nina (PLoS ONE;12(7), Journal article; Peer reviewed, 2017-07-13)
      Background and aims Chronic hepatitis C virus (HCV) genotype 3 infection with advanced liver disease has emerged as the most challenging to treat. We retrospectively assessed the treatment outcome of sofosbuvir (SOF) based ...
    • Somatic EP300-G211S mutations are associated with overall somatic mutational patterns and breast cancer specific survival in triple-negative breast cancer 

      Bemanian, Vahid; Noone, John Cristopher; Sauer, Torill; Touma, Joel Joul; Vetvik, Katja K.; Söderberg-Naucler, Cecilia; Lindstrøm, Jonas Christoffer; Bukholm, Ida Rashida Khan; Kristensen, Vessela N.; Geisler, Jürgen (Breast cancer research and treatment;172(2), Journal article; Peer reviewed, 2018-08-21)
      Purpose We have compared the mutational profiles of human breast cancer tumor samples belonging to all major subgroups with special emphasis on triple-negative breast cancer (TNBC). Our major goal was to identify specific ...