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dc.contributor.authorOttestad, Inger
dc.contributor.authorVogt, Kjell Gjermund
dc.contributor.authorRetterstøl, Kjetil
dc.contributor.authorMyhrstad, Mari
dc.contributor.authorHaugen, John-Erik
dc.contributor.authorNilsson, Astrid
dc.contributor.authorRavn-Haren, Gitte
dc.contributor.authorNordvi, Berit
dc.contributor.authorBrønner, Kirsti Wettre
dc.contributor.authorAndersen, Lene Frost
dc.contributor.authorHolven, Kirsten Bjørklund
dc.contributor.authorUlven, Stine Marie
dc.date.accessioned2011-12-20T07:26:51Z
dc.date.available2011-12-20T07:26:51Z
dc.date.issued2011
dc.identifier.citationInger Ottestad, Gjermund Vogt, Kjetil Retterstøl, Mari C. Myhrstad, John-Erik Haugen, Astrid Nilsson, Stine M. Ulven et al. Oxidised fish oil does not influence established markers of oxidative stress in healthy human subjects: a randomised controlled trial. British Journal of Nutrition, Available on CJO 2011 doi:10.1017/S0007114511005484en_US
dc.identifier.issn0007-1145
dc.identifier.urihttps://hdl.handle.net/10642/1011
dc.description.abstractIntake of fish oil reduces the risk of CHD and CHD deaths. Marine n-3 fatty acids (FA) are susceptible to oxidation, but to our knowledge, the health effects of intake of oxidised fish oil have not previously been investigated in human subjects. The aim of the present study was to investigate markers of oxidative stress, lipid peroxidation and inflammation, and the level of plasma n-3 FA after intake of oxidised fish oil. In a double-blinded randomised controlled study, healthy subjects (aged 18–50 years, n 54) were assigned into one of three groups receiving capsules containing either 8 g/d of fish oil (1·6 g/d EPA þ DHA; n 17), 8 g/d of oxidised fish oil (1·6 g/d EPA þ DHA; n 18) or 8 g/d of high-oleic sunflower oil (n 19). Fasting blood and morning spot urine samples were collected at weeks 0, 3 and 7. No significant changes between the different groups were observed with regard to urinary 8-iso-PGF2a; plasma levels of 4-hydroxy-2-hexenal, 4-hydroxy-2-nonenal and a-tocopherol; serum high sensitive C-reactive protein; or activity of antioxidant enzymes in erythrocytes. A significant increase in plasma level of EPA þ DHA was observed in both fish oil groups, but no significant difference was observed between the fish oil groups. No changes in a variety of in vivo markers of oxidative stress, lipid peroxidation or inflammation were observed after daily intake of oxidised fish oil for 3 or 7 weeks, indicating that intake of oxidised fish oil may not have unfavourable short-term effects in healthy human subjectsen_US
dc.language.isoengen_US
dc.publisherCambridge University Pressen_US
dc.relation.ispartofseriesBritish Journal of Nutrition;
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Ernæring: 811en_US
dc.subjectFiskeoljeen_US
dc.subjectOmega-3 fettsyreren_US
dc.subjectFolkehelseen_US
dc.titleOxidised fish oil does not influence established markers of oxidative stress in healthy human subjects: a randomised controlled trialen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionUtgivers pdf
dc.identifier.doihttp://dx.doi.org/10.1017/S0007114511005484


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