• Chronic hyperglycemia reduces substrate oxidation and impairs metabolic switching of human myotubes 

      Aas, Vigdis; Hessvik, Nina Pettersen; Wettergreen, Marianne; Hvammen, Andreas Wensaas; Hallén, Stefan; Thoresen, G. Hege; Rustan, Arild (Biochimica et Biophysica Acta - Molecular Basis of Disease;1812 (1), Journal article; Peer reviewed, 2011-01)
      Skeletal muscle of insulin resistant individuals is characterized by lower fasting lipid oxidation and reduced ability to switch between lipid and glucose oxidation. The purpose of the present study was to examine if chronic ...
    • Increased glycolysis and higher lactate production in hyperglycemic myotubes 

      Lund, Jenny; Ouwens, DM; Wettergreen, Marianne; Bakke, Siril Skaret; Thoresen, G. Hege; Aas, Vigdis (Cells;Volume 8, Issue 9, Journal article; Peer reviewed, 2019-09-18)
      Previous studies have shown that chronic hyperglycemia impairs glucose and fatty acid oxidation in cultured human myotubes. To further study the hyperglycemia-induced suppression of oxidation, lactate oxidation, mitochondrial ...