• Bone Turnover Markers After Standard and Distal Roux-en-Y Gastric Bypass: Results from a Randomized Controlled Trial 

      Svanevik, Marius; Risstad, Hilde; Hofsø, Dag; Høgestøl, Ingvild Kristine; Kristinsson, Jon Adalsteinn; Sandbu, Rune; Småstuen, Milada Cvancarova; Thorsby, Per Medbøe; Mala, Tom; Hjelmesæth, Jøran (Obesity Surgery;29, pages 2886–2895 (2019), Journal article; Peer reviewed, 2019-05-08)
      Background: Roux-en-Y gastric bypass is associated with increased risk of bone fractures. Malabsorptive procedures may be associated with secondary hyperparathyroidism and detrimental effects on bone health. We aimed to ...
    • Correlation of body weight and composition with hepatic activities of cytochrome P450 enzymes 

      Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K.; Vistnes, Maria; Hjelmesæth, Jøran; Sandbu, Rune; Johnson, Line Kristin; Angeles, Philip Carlo Soriano; Jansson-Löfmark, Rasmus; Karlsson, Cecilia; Andersson, Shalini; Åsberg, Anders; Andersson, Tommy B.; Christensen, Hege Staaland (Journal of Pharmaceutical Sciences;Volume 110, Issue 1, Journal article; Peer reviewed, 2020-10-18)
      Obesity is associated with comorbidities of which pharmacological treatment is needed. Physiological changes associated with obesity may influence the pharmacokinetics of drugs, but the effect of body weight on drug ...
    • Gastric bypass versus sleeve gastrectomy in patients with type 2 diabetes (Oseberg): a single-centre, triple-blind, randomised controlled trial 

      Hofsø, Dag; Fatima, Farhat; Borgeraas, Heidi; Birkeland, Kåre I.; Gulseth, Hanne Løvdal; Hertel, Jens Kristoffer; Johnson, Line Kristin; Lindberg, Morten; Nordstrand, Njord; Småstuen, Milada Cvancarova; Stefanovski, Darko; Svanevik, Marius; Valderhaug, Tone Gretland; Sandbu, Rune; Hjelmesæth, Jøran (The Lancet Diabetes and Endocrinology;Volume 7, ISSUE 12, Journal article; Peer reviewed, 2019-10-30)
      Background: The comparative effectiveness of various bariatric procedures on remission of type 2 diabetes remains debated. We aimed to compare the two most commonly used procedures, hypothesising higher remission rates ...
    • Gastrointestinal Hormones and β-Cell Function After Gastric Bypass and Sleeve Gastrectomy: A Randomized Controlled Trial (Oseberg) 

      Fatima, Farhat; Hjelmesæth, Jøran Sture; Birkeland, Kåre Inge; Gulseth, Hanne Løvdal; Hertel, Jens Kristoffer; Svanevik, Marius; Sandbu, Rune; Småstuen, Milada Cvancarova; Hartmann, Bolette; Holst, Jens Juul; Hofsø, Dag (Journal of Clinical Endocrinology and Metabolism;, Peer reviewed; Journal article, 2021-08-03)
      Context Whether Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) differentially affect postprandial gastrointestinal hormones and β-cell function in type 2 diabetes remains unclear. Objective To compare ...
    • Myotubes from Severely Obese Type 2 Diabetic Subjects Accumulate Less Lipids and Show Higher Lipolytic Rate than Myotubes from Severely Obese Non-Diabetic Subjects 

      Bakke, Siril Skaret; Feng, Yuan Zeng; Nikolic, Natasa; Kase, Eili Tranheim; Moro, Cedric; Stensrud, Camilla; Damlien, Lisbeth; Ludahl, Marianne Odnakk; Sandbu, Rune; Solheim, Brita Marie; Rustan, Arild; Hjelmesæth, Jøran; Thoresen, G. Hege; Aas, Vigdis (Journal article; Peer reviewed, 2015-03-19)
      About 80% of patients with type 2 diabetes are classified as overweight. However, only about 1/3 of severely obese subjects have type 2 diabetes. This indicates that several se- verely obese individuals may possess certain ...
    • Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity 

      Kvitne, Kine Eide; Krogstad, Veronica; Wegler, Christine; Johnson, Line Kristin; Kringen, Marianne K.; Hovd, Markus Herberg; Hertel, Jens Kristoffer; Heijer, Maria; Sandbu, Rune; Skovlund, Eva; Artursson, Per; Karlsson, Cecilia; Andersson, Shalini; Andersson, Tommy B.; Hjelmesæth, Jøran Sture; Åsberg, Anders; Jansson-Löfmark, Rasmus; Christensen, Hege; Robertsen, Ida (British Journal of Clinical Pharmacology;Volume 88, Issue 9, Peer reviewed; Journal article, 2022-04-11)
      Aim: Roux-en-Y gastric bypass (RYGB) may influence drug disposition due to surgery-induced gastrointestinal alterations and/or subsequent weight loss. The objective was to compare short- and long-term effects of RYGB and ...