Browsing ODA Open Digital Archive by Author "Rustan, Arild"
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Are cultured human myotubes far from home?
Aas, Vigdis; Bakke, Siril Skaret; Feng, Yuan Zeng; Kase, Eili Tranheim; Jensen, Jørgen; Bajpeyi, Sudip; Thoresen, G. Hege; Rustan, Arild (Cell and tissue research;354(3), Journal article; Peer reviewed, 2013-12)Satellite cells can be isolated from skeletal muscle biopsies, activated to proliferating myoblasts and differentiated into multinuclear myotubes in culture. These cell cultures represent a model system for intact human ... -
Benfotiamine increases glucose oxidation and downregulates NADPH oxidase 4 expression in cultured human myotubes exposed to both normal and high glucose concentrations
Fraser, David; Hessvik, Nina Pettersen; Nikolic, Natasa; Aas, Vigdis; Hanssen, Kristian Folkvord; Bøhn, Siv Kjølsrud; Thoresen, G. Hege; Rustan, Arild (Genes & Nutrition;Online before print, Journal article; Peer reviewed, 2011-10-09)The aim of the present work was to study the effects of benfotiamine (S-benzoylthiamine O-monophosphate) on glucose and lipid metabolism and gene expression in differentiated human skeletal muscle cells (myotubes) incubated ... -
Chronic hyperglycemia reduces substrate oxidation and impairs metabolic switching of human myotubes
Aas, Vigdis; Hessvik, Nina Pettersen; Wettergreen, Marianne; Hvammen, Andreas Wensaas; Hallén, Stefan; Thoresen, G. Hege; Rustan, Arild (Biochimica et Biophysica Acta - Molecular Basis of Disease;1812 (1), Journal article; Peer reviewed, 2011-01)Skeletal muscle of insulin resistant individuals is characterized by lower fasting lipid oxidation and reduced ability to switch between lipid and glucose oxidation. The purpose of the present study was to examine if chronic ... -
Metabolic switching of human skeletal muscle cells in vitro
Thoresen, G. Hege; Hessvik, Nina Pettersen; Bakke, Siril Skaret; Aas, Vigdis; Rustan, Arild (Prostaglandins leukotrienes and essential fatty acids;85 (5), Journal article; Peer reviewed, 2011-05-05)In this review we will focus on external factors that may modify energy metabolism in human skeletal muscle cells (myotubes) and the ability of the myotubes to switch between lipid and glucose oxidation. We describe the ... -
Myotubes from Severely Obese Type 2 Diabetic Subjects Accumulate Less Lipids and Show Higher Lipolytic Rate than Myotubes from Severely Obese Non-Diabetic Subjects
Bakke, Siril Skaret; Feng, Yuan Zeng; Nikolic, Natasa; Kase, Eili Tranheim; Moro, Cedric; Stensrud, Camilla; Damlien, Lisbeth; Ludahl, Marianne Odnakk; Sandbu, Rune; Solheim, Brita Marie; Rustan, Arild; Hjelmesæth, Jøran; Thoresen, G. Hege; Aas, Vigdis (Journal article; Peer reviewed, 2015-03-19)About 80% of patients with type 2 diabetes are classified as overweight. However, only about 1/3 of severely obese subjects have type 2 diabetes. This indicates that several se- verely obese individuals may possess certain ... -
Substrate oxidation in primary human skeletal muscle cells is influenced by donor age
Aas, Vigdis; Thoresen, G. Hege; Rustan, Arild; Lund, Jenny (Cell and Tissue Research;382 (2020), Journal article; Peer reviewed, 2020-09-08)Primary human myotubes represent an alternative system to intact skeletal muscle for the study of human diseases related to changes in muscle energy metabolism. This work aimed to study if fatty acid and glucose metabolism ...