Browsing ODA Open Digital Archive by Author "Nygaard, Øystein Petter"
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Antibiotic treatment In patients with chronic low back pain and Modic changes (the AIM study): study protocol for a randomised controlled trial.
Storheim, Kjersti; Espeland, Ansgar; Grøvle, Lars; Skouen, Jan Sture; Assmus, Jörg; Anke, Audny; Froholdt, Anne; Pedersen, LM; Haugen, AJ; Fors, Terese; Schistad, Ellina Iordanova; Lutro, Olav; Marchand, Gunn Hege; Kadar, Thomas; Vetti, Nils; Randen, Solfrid; Nygaard, Øystein Petter; Brox, Jens Ivar; Grotle, Margreth; Zwart, JA (Journal article; Peer reviewed, 2017)Background A previous randomised controlled trial (RCT) of patients with chronic low back pain (LBP) and vertebral bone marrow (Modic) changes (MCs) on magnetic resonance imaging (MRI), reported that a 3-month, high-dose ... -
Can we define success criteria for lumbar disc surgery? Estimates for a substantial amount of improvement in core outcome measures
Solberg, Tore; Johnsen, Lars Gunnar; Nygaard, Øystein Petter; Grotle, Margreth (Acta Orthopaedica;84(2), Journal article; Journal article; Peer reviewed, 2013)Background and purpose: A successful outcome after lumbar discectomy indicates a substantial improvement. To use the cutoffs for minimal clinically important difference (MCID) as success criteria has a large potential bias, ... -
Clinical effect modifiers of antibiotic treatment in patients with chronic low back pain and Modic changes - Secondary analyses of a randomised, placebo-controlled trial (the AIM study)
Bråten, Lars Christian Haugli; Grøvle, Lars; Espeland, Ansgar; Pripp, Are Hugo; Grotle, Margreth; Hellum, Christian; Haugen, Anne Julsrud; Froholdt, Anne; Rolfsen, Mads Peder; Nygaard, Øystein Petter; Lutro, Olav; Kristoffersen, Per Martin; Anke, Audny; Schistad, Ellina Iordanova; Skouen, Jan Sture; Brox, Jens Ivar; Zwart, John-Anker; Storheim, Kjersti (BMC Musculoskeletal Disorders;21, Article number: 458 (2020), Journal article; Peer reviewed, 2020-07-13)Background: Randomised trials on antibiotic treatment for patients with chronic low back pain and vertebral endplate changes visible on MRI (Modic changes) have shown mixed results. A possible explanation might be a real ... -
Comparison of the SF6D, the EQ5D, and the oswestry disability index in patients with chronic low back pain and degenerative disc disease
Johnsen, Lars Gunnar; Hellum, Christian; Nygaard, Øystein Petter; Storheim, Kjersti; Brox, Jens Ivar; Rossvoll, Ivar; Leivseth, Gunnar; Grotle, Margreth (BMC musculoskeletal disorders;14(1), Journal article; Peer reviewed, 2013-04-26)Background The need for cost effectiveness analyses in randomized controlled trials that compare treatment options is increasing. The selection of the optimal utility measure is important, and a central question is ... -
Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre trial
Bråten, Lars Christian Haugli; Rolfsen, Mads Peder; Espeland, Ansgar; Wigemyr, Monica; Assmus, Jörg; Froholdt, Anne; Haugen, Anne Julsrud; Marchand, Gunn Hege; Kristoffersen, Per M; Lutro, Olav; Randen, Sigrun; Wilhelmsen, Maja; Winsvold, Bendik K S; Kadar, Thomas; Holmgard, Thor Einar; Vigeland, Maria Dehli; Vetti, Nils; Nygaard, Øystein Petter; Lie, Benedicte Alexandra; Hellum, Christian; Anke, Audny; Grotle, Margreth; Schistad, Ellina Iordanova; Skouen, Jan Sture; Grøvle, Lars; Brox, Jens Ivar; Zwart, John-Anker; Storheim, Kjersti (BMJ; 2019;367:l5654, Journal article; Peer reviewed, 2019-08-29)Objective: To assess the efficacy of three months of antibiotic treatment compared with placebo in patients with chronic low back pain, previous disc herniation, and vertebral endplate changes (Modic changes). Design: ... -
Low Back Pain With Persistent Radiculopathy; the Clinical Role of Genetic Variants in the Genes SOX5, CCDC26/GSDMC and DCC
Lie, Marie; Pedersen, Linda Margareth; Heuch, Ingrid; Winsvold, Bendik K S; Gjerstad, Johannes; Hasvik, Eivind Olay; Nygaard, Øystein Petter; Grotle, Margreth; Matre, Dagfinn; Zwart, John Anker Henrik; Nilsen, Kristian Bernhard (Frontiers in Genetics;January 2022 | Volume 12 | Article 757632, Peer reviewed; Journal article, 2022-01-24)In a recently published genome-wide association study (GWAS) chronic back pain was associated with three loci; SOX5, CCDC26/GSDMC and DCC. This GWAS was based on a heterogeneous sample of back pain disorders, and it is ... -
A prognostic model for failure and worsening after lumbar microdiscectomy: a multicenter study from the Norwegian Registry for Spine Surgery
Werner, David Andreas Thomas; Grotle, Margreth; Småstuen, Milada Cvancarova; Gulati, Sasha; Nygaard, Øystein Petter; Salvesen, Øyvind; Ingebrigtsen, Tor; Solberg, Tore (Acta Neurochirurgica;163, pages (2021), Peer reviewed; Journal article, 2021-07-10)Objective: To develop a prognostic model for failure and worsening 1 year after surgery for lumbar disc herniation. Methods: This multicenter cohort study included 11,081 patients operated with lumbar microdiscectomy, ... -
Validation of the Nepali versions of the NeckDisability Index and the Numerical Rating Scalefor Neck Pain
Shrestha, Dipak; Shrestha, Rohit; Grotle, Margreth; Nygaard, Øystein Petter; Solberg, Tore (Spine;Volume 46, issue 5, Journal article; Peer reviewed, 2020-03-01)Study Design. A cross-sectional study with a test–retest design. Objective. To translate and culturally adapt the numerical rating scale (NRS) for neck pain intensity and the Neck Disability Index (NDI), and asses their ...