Browsing ODA Open Digital Archive by Author "Bergersen, Linda Hildegard"
Now showing items 1-5 of 5
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Altered α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor function and expression in hippocampus in a rat model of attention-deficit/hyperactivity disorder (ADHD)
Medin, Tirill; Jensen, Vidar; Skare, Øivind; Storm-Mathisen, Jon; Hvalby, Øyvind Christian; Bergersen, Linda Hildegard (Behavioural Brain Research;Volume 360, 15 March 2019, Journal article; Peer reviewed, 2018-12-12)Glutamatergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) carry the bulk of excitatory synaptic transmission. Their modulation plays key roles in synaptic plasticity, which underlies hippocampal ... -
Blood lactate dynamics in awake and anaesthetized mice after intraperitoneal and subcutaneous injections of lactate—sex matters
Haugen, Øyvind Pernell; Vallenari, Evan Michael; Belhaj, Imen; Småstuen, Milada Cvancarova; Storm-Mathisen, Jon; Bergersen, Linda Hildegard; Åmellem, Ingrid (PeerJ;8: e8328, Journal article; Peer reviewed, 2020-12-02)Lactate treatment has shown a therapeutic potential for several neurological diseases, including Alzheimer’s disease. In order to optimize the administration of lactate for studies in mouse models, we compared blood lactate ... -
Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1
Morland, Cecilie; Andersson, Krister; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv; Gille, Andreas; Rinholm, Johanne Egge; Palibrk, Vuk; Diget, Elisabeth Holm; Kennedy, Lauritz Hagen; Stølen, Tomas; Hennestad, Eivind; Moldestad, Olve; Cai, Yiqing; Puchades, Maja Amedjkouh; Offermanns, Stefan; Vervaeke, Koen Gerard Alois; Bjørås, Magnar; Wisløff, Ulrik; Storm-Mathisen, Jon; Bergersen, Linda Hildegard (Journal article; Peer reviewed, 2017)Physical exercise can improve brain function and delay neurodegeneration; however, the initial signal from muscle to brain is unknown. Here we show that the lactate receptor (HCAR1) is highly enriched in pial fibroblast-like ... -
L‐lactate induces neurogenesis in the mouse ventricular‐subventricular zone via the lactate receptor HCA1
Lambertus, Marvin; Øverberg, Linda Thøring; Andersson, Krister Andreas; Hjelden, Malin Sørli; Hadzic, Alena; Haugen, Øyvind Pernell; Storm-Mathisen, Jon; Bergersen, Linda Hildegard; Geiseler, Samuel; Morland, Cecilie (Acta Physiologica;Volume 231, Issue 3, Peer reviewed; Journal article, 2020-11-26)Aim: Adult neurogenesis occurs in two major niches in the brain: the subgranular zone of the hippocampal formation and the ventricular-subventricular zone. Neurogenesis in both niches is reduced in ageing and neurological ... -
Upregulation of the lactate transporter monocarboxylate transporter 1 at the blood-brain barrier in a rat model of attention-deficit/hyperactivity disorder suggests hyperactivity could be a form of self-treatment
Medin, Tirill; Medin, Hege; Hefte, Marita Brandsar; Storm-Mathisen, Jon; Bergersen, Linda Hildegard (Behavioural Brain Research;Volume 360, 15 March 2019, Journal article; Peer reviewed, 2018-12-11)The energy deficit hypothesis of attention-deficit/hyperactivity disorder (ADHD) suggests that low lactate production by brain astrocytes causes the symptoms of the disorder. Astrocytes are the main producers of lactate ...