• Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19 

      Aamodt, Anne Hege; Høgestøl, Einar August; Popperud, Trine Haug; Holter, Jan Cato; Dyrhol-Riise, Anne Ma; Tonby, Kristian; Stiksrud, Birgitte; Paulsen, Else Quist; Berge, Tone; Barratt-Due, Andreas; Aukrust, Pål; Heggelund, Lars; Blennow, Kaj; Zetterberg, Henrik; Harbo, Hanne Flinstad (Journal of Neurology;, Peer reviewed; Journal article, 2021-03-20)
      Objective To test the hypotheses that blood biomarkers for nervous system injury, serum concentrations of neurofilament light chain protein (NfL) and glial fibrillary acidic protein (GFAp) can serve as biomarkers for disease ...
    • CD8 + T cell gene expression analysis identifies differentially expressed genes between multiple sclerosis patients and healthy controls 

      Brorson, Ina Skaara; Eriksson, Anna Maria; Leikfoss, Ingvild Sørum; Vitelli, Valeria; Celius, Elisabeth Gulowsen; Luders, Torben; Berge, Tone; Harbo, Hanne Flinstad; Nilsen, Hilde; Bos-Haugen, Steffan Daniël (Multiple Sclerosis Journal, Experimental, Translational and Clinical;Volume: 6, issue: 4, Journal article; Peer reviewed, 2020-12-09)
      Background: Genetic and clinical observations have indicated T cells are involved in MS pathology. There is little insight in how T cells are involved and whether or not these can be used as markers for MS. Objectives: ...
    • Exploring the role of the multiple sclerosis susceptibility gene CLEC16A in T cells 

      Eriksson, Anna Maria; Leikfoss, Ingvild Sørum; Abrahamsen, Greger; Sundvold, Vibeke; Isom, Martine Mesel; Keshari, Pankaj; Rognes, Torbjørn; Landsverk, Ole J. B.; Bos, Steffan Daniel; Harbo, Hanne Flinstad; Spurkland, Anne; Berge, Tone (Scandinavian Journal of Immunology;, Peer reviewed; Journal article, 2021-05-02)
      C-type lectin-like domain family 16 member A (CLEC16A) is associated with autoimmune disorders, including multiple sclerosis (MS), but its functional relevance is not completely understood. CLEC16A is expressed in several ...
    • Human endonuklease V- Isoformer og aktivitet i makrofager og T-celler 

      Storbråten, Marielle; Skurdal, Eivind (Bachelor thesis, 2019-05-23)
      Human Endonuklease V er et enzym som kutter ved inosiner i RNA in vitro. Den overordnede hensikten med denne oppgaven var å studere isoformene 282, 308 og 309 for å få en bedre forståelse av in vivo funksjonen til human ...
    • Humoral immunity to SARS-CoV-2 mRNA vaccination in multiple sclerosis: the relevance of time since last rituximab infusion and first experience from sporadic revaccinations 

      König, Marton; Lorentzen, Åslaug Rudjord; Torgauten, Hilde Marie; Tran, The Trung; Schikora-Rustad, Stine; Vaage, Eline Benno; Mygland, Åse Daasvand; Wergeland, Stig; Aarseth, Jan Harald; Aaberge, Ingeborg Sundsvalen; Torkildsen, Øivind; Holmøy, Trygve; Berge, Tone; Myhr, Kjell-Morten; Harbo, Hanne-Cathrin Flinstad; Andersen, Jan Terje; Munthe, Ludvig Andre; Søraas, Arne Vasli; Celius, Elisabeth Gulowsen; Vaage, John T.; Lund-Johansen, Fridtjof; Nygaard, Gro Owren (Journal of Neurology, Neurosurgery and Psychiatry;, Peer reviewed; Journal article, 2021-10-20)
      Introduction: The effect of disease-modifying therapies (DMT) on vaccine responses is largely unknown. Understanding the development of protective immunity is of paramount importance to fight the COVID-19 pandemic. Objective: ...
    • Humoral immunity to SARS-CoV-2 mRNA vaccination in multiple sclerosis: The relevance of time since last rituximab infusion and first experience from sporadic revaccinations 

      König, Marton; Lorentzen, Åslaug Rudjord; Torgauten, Hilde Marie; Tran, Trung; Schikora-Rustad, Stine; Vaage, Eline Benno; Mygland, Åse Daasvand; Wergeland, Stig; Aarseth, Jan Harald; Aaberge, Ingeborg Sundsvalen; Torkildsen, Øivind; Holmøy, Trygve; Berge, Tone; Myhr, Kjell-Morten; Harbo, Hanne-Cathrin Flinstad; Andersen, Jan Terje; Munthe, Ludvig Andre; Søraas, Arne Vasli; Celius, Elisabeth Gulowsen; Vaage, John T.; Lund-Johansen, Fridtjof; Nygaard, Gro Owren (Peer reviewed; Journal article, 2021)
      Introduction The effect of disease-modifying therapies (DMT) on vaccine responses is largely unknown. Understanding the development of protective immunity is of paramount importance to fight the COVID-19 pandemic. Objective ...
    • Impact of treatment on cellular immunophenotype in MS: A cross-sectional study 

      Cellerino, Maria; Ivaldi, Frederico; Pardini, Matteo; Rotta, Gianluca; Vila, Gemma; Bäcker-Koduah, Priscilla; Berge, Tone; Laroni, Alice; Lapucci, Caterina; Novi, Giovanni; Boffa, Giacomo; Sbragia, Elvira; Palmeri, Serena; Aassayer, Susanna; Høgestøl, Einar August; Campi, Cristina; Piana, Michele; Inglese, Matilde; Friedemann, Paul; Harbo, Hanne Flinstad; Villoslada, Pablo; Kerlero de Rosbo, Nicole; Uccelli, Antonio (Neurology, Neuroimmunology and Neuroinflammation;volume 7, issue 3, Journal article; Peer reviewed, 2020-03-05)
      Objective: To establish cytometry profiles associated with disease stages and immunotherapy in MS. Methods: Demographic/clinical data and peripheral blood samples were collected from 227 patients with MS and 82 sex- and ...
    • Increased DNA methylation of SLFN12 in CD4+ and CD8+ T cells from multiple sclerosis patients 

      Rhead, Brooke; Brorson, Ina Skaara; Berge, Tone; Adams, Cameron; Quach, Hong; Moen, Stine Marit; Berg-Hansen, Pål; Celius, Elisabeth Gulowsen; Sangurdekar, Dipen; Bronson, Paola G.; Lea, Rodney A.; Burnard, Sean; Maltby, Vicky E.; Scott, Rodney J; Lechner-Scott, Jeannette; Harbo, Hanne Flinstad; Bos, Steffan Daniel; Barcellos, Lisa F (PLoS ONE;13 (10): e0206511, Journal article; Journal article; Peer reviewed, 2018-10-31)
      DNA methylation is an epigenetic mark that is influenced by environmental factors and is associated with changes to gene expression and phenotypes. It may link environmental exposures to disease etiology or indicate important ...
    • No differential gene expression for CD4+ T cells of MS patients and healthy controls. 

      Brorson, Ina Skaara; Eriksson, Anna; Leikfoss, Ingvild Sørum; Celius, Elisabeth Gulowsen; Berg-Hansen, Pål; Barcellos, Lisa F.; Berge, Tone; Harbo, Hanne Flinstad; Bos, Steffan Daniel (Multiple Sclerosis Journal - Experimental, Translational and Clinical;Volume 5(2), Journal article; Peer reviewed, 2019-05-20)
      Background: Multiple sclerosis-associated genetic variants indicate that the adaptive immune system plays an important role in the risk of developing multiple sclerosis. It is currently not well understood how these multiple ...
    • Nye forbindelser i bekjempelsen mot antibiotikaresistent tuberkulose 

      Kubendraraj, Shivani; Sanjeevan, Sharuga (Bachelor thesis, 2022)
      I dette prosjektet ble fire gramnegative bakterier (Pseudomonas aeruginosa, Acinetobacter baumannii, Enterobacter cloacae og Klebsiella pneumoniae), en laboratoriestamme av Mycobacterium tuberculosis (MTB), og to ...
    • Quantitative proteomic analyses of CD4+ and CD8+ T cells reveal differentially expressed proteins in multiple sclerosis patients and healthy controls 

      Berge, Tone; Eriksson, Anna; Brorson, Ina Skaara; Høgestøl, Einar August; Berg-Hansen, Pål; Døskeland, Anne Marie Simonne; Mjaavatten, Olav; Bos, Steffan Daniel; Harbo, Hanne Flinstad; Berven, Frode (Clinical Proteomics;16, Article number: 19 (2019), Peer reviewed; Journal article, 2019-04-27)
      Background: Multiple sclerosis (MS) is an autoimmune, neuroinflammatory disease, with an unclear etiology. How‑ ever, T cells play a central role in the pathogenesis by crossing the blood–brain‑barrier, leading to inflammation ...
    • A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis 

      Madireddy, Lohith; Patsopoulos, Nikolaos A.; Cotsapas, Chris; Bos, Steffan Daniel; Beecham, Ashley; McCauley, Jacob; Kim, Kicheol; Jia, Xiaoming; Santaniello, Adam; Caillier, Stacy J.; Andlauer, Till F.M.; Barcellos, Lisa F.; Berge, Tone; Bernardinelli, Luisa; Martinelli-Boneschi, Filippo; Booth, David R.; Briggs, Farren; Celius, Elisabeth Gulowsen; Comabella, Manuel; Comi, Giancarlo; Cree, Bruce A.C.; D'Alfonso, Sandra; Dedham, Katrina; Duquette, Pierre; Efthimios, Dardiotis; Esposito, Federica; Fontaine, Bertrand; Gasperi, Christiane; Goris, An; Dubois, Bénédicte; Gourraud, Pierre-Antoine; Hadjigeorgiou, Georgios; Haines, Jonathan; Hawkins, Clive; Hemmer, Bernhard; Hintzen, Rogier; Horakova, Dana; Isobe, Noriko; Kalra, Seema; Kira, Jun-ichi; Khalil, Michael; Kockum, Ingrid; Lill, Christina M.; Lincoln, Matthew R; Luessi, Felix; Martin, Roland; Oturai, Annette; Palotie, Aarno; Pericak-Vance, Margaret A.; Henry, Roland; Saarela, Janna; Ivinson, Adrian; Olsson, Tomas; Taylor, Bruce V.; Stewart, Graeme J.; Harbo, Hanne Flinstad; Compston, Alastair; Hauser, Stephen L.; Hafler, David A.; Zipp, Frauke; De Jager, Philip; Sawcer, Stephen; Oksenberg, Jorge R.; Baranzini, Sergio E. (Nature Communications;10, Article number: 2236 (2019), Journal article; Peer reviewed, 2019-05-20)
      Genome-wide association studies (GWAS) have identified more than 50,000 unique associations with common human traits. While this represents a substantial step forward, establishing the biology underlying these associations ...
    • A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis. 

      Madireddy, L; Patsopoulos, NA; Cotsapas, C; Bos, Steffan Daniel; Beecham, Ashley; McCauley, J; Kim, K; Jia, X; Santaniello, A; Caillier, SJ; Andlauer, TFM; Barcellos, Lisa; Berge, Tone; Bernardinelli, L; Martinelli-Boneschi, F; Booth, D; Briggs, Farren; Celius, Elisabeth Gulowsen; Comabella, M; Comi, G; Cree, BAC; D'Alfonso, S; Dedham, K; Duquette, P.; Dardiotis, E; Esposito, F; Gasperi, Christiane; Goris, A; Dubois, B; Gourraud, PA; Hadjigeorgiou, GM; Haines, J; Hawkins, C; Hemmer, B; Hintzen, R; Horakova, D; Isobe, N; Kalra, S; Kira, Jun-ichi; Khalil, M; Kockum, I; Lill, CM; Lincoln, Michelle; Luessi, F; Martin, R; Oturai, A; Palotie, A; Pericak-Vance, MA; Henry, R; Saarela, J; Ivinson, Adrian; Olsson, Thomas; Taylor, Bruce; Stewart, GJ; Harbo, Hanne Flinstad; Compston, A; Hauser, SL; Hafler, DA; Zipp, F; De Jager, P; Sawcer, S; Oksenberg, JR; Baranzini, SE (Nature Communications;10, Article number: 2236 (2019), Journal article; Peer reviewed, 2019-03-26)
      Genome-wide association studies (GWAS) have identified more than 50,000 unique associations with common human traits. While this represents a substantial step forward, establishing the biology underlying these associations ...