Can dual energy CT with fast kV-switching determine renal stone composition accurately?
Journal article, Peer reviewed
Accepted version
Permanent lenke
https://hdl.handle.net/10642/8415Utgivelsesdato
2020-03-23Metadata
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Originalversjon
Mussmann B, Hardy M, Jung, Ding M, Osther PJ, Graumann. Can dual energy CT with fast kV-switching determine renal stone composition accurately?. Academic Radiology. 2020 https://dx.doi.org/10.1016/j.acra.2020.02.007Sammendrag
Rationale and objectives
To determine whether a single source CT system utilizing fast kV switching and low
dose settings can characterize (diameter and chemical composition) renal stones
accurately when compared infrared spectroscopy
Materials and methods
The chemical composition of 15 renal stones was determined using Fourier transform
infrared spectroscopy. The stones were inserted into a porcine kidney and placed
within a water tank for CT scanning using both fast kV switching dual energy and
standard protocols. Effective atomic number of each stone was measured using
scanner software. Stone diameter measurements were repeated twice to determine
intra-rater variation and compared to actual stone diameter as measured by micro CT.
Results
The chemical composition of three stones (1 calcium phosphate and 2 carbonite
apatite) could not be determined using the scanner software. The composition of 10/12
remaining stones was correctly identified using DECT (83% absolute agreement;
k=0.69). No statistical difference (p=0.051) was noted in the mean stone diameter as
measured by clinical CT and micro CT.
Conclusion
DECT using fast kV switching may potentially be developed as a low dose clinical tool
for identifying and classifying renal stones in vivo supporting clinical decision-making.