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dc.contributor.authorChandra, Anupam
dc.contributor.authorRøsjø, Helge
dc.contributor.authorEide, Ivar Anders
dc.contributor.authorVigen, Thea
dc.contributor.authorIhle-Hansen, Håkon
dc.contributor.authorOrstad, Eivind Bjørkan
dc.contributor.authorRønning, Ole M
dc.contributor.authorLyngbakken, Magnus
dc.contributor.authorBerge, Trygve
dc.contributor.authorSchmidt, Erik Berg
dc.contributor.authorOmland, Torbjørn
dc.contributor.authorTveit, Arnljot
dc.contributor.authorSvensson, My Hanna Sofie
dc.date.accessioned2020-02-19T09:35:55Z
dc.date.available2020-02-19T09:35:55Z
dc.date.issued2019-05-23
dc.identifier.citationChandra, A., Røsjø, H., Eide, I. A., Vigen, T., Ihle-Hansen, H., Orstad, E. B., ... & Omland, T. (2019). Plasma marine n-3 polyunsaturated fatty acids and cardiovascular risk factors: data from the ACE 1950 study. European journal of nutrition, 1-11.en
dc.identifier.issn1436-6207
dc.identifier.urihttps://hdl.handle.net/10642/8140
dc.description.abstractAbstract Purpose A high intake of marine n-3 polyunsaturated fatty acids (PUFAs) might improve cardiovascular (CV) health. We conducted a cross-sectional study to investigate associations between plasma phospholipid levels of marine n-3 PUFAs and CV risk factors, educational level, physical activity and smoking habits. Methods A total of 3706 individuals from a general population, all born in 1950 and residing in Akershus County, Norway, were included in this study. The main statistical approach was multivariable adjusted linear regression. Results Plasma marine n-3 PUFA levels ranged from 2.7 to 20.3 wt%, with a median level of 7.7 wt% (interquartile range 4.3–11.1 wt%). High levels of plasma marine n-3 PUFAs were associated with lower serum triglycerides [Standardized regression coefficient (Std.β-coeff.) − 0.14, p < 0.001], body mass index (Std. β-coeff. −0.08, p < 0.001), serum creatinine (Std. β-coeff. -0.03, p = 0.05), C-reactive protein levels (Std. β-coeff. – 0.03, p = 0.04), higher levels of serum high-density lipoprotein cholesterol (Std. β-coeff. 0.08, p < 0.001) and low-density lipoprotein cholesterol (Std. β-coeff. 0.04, p = 0.003). High levels of plasma marine n-3 PUFAs were also associated with lower glycated hemoglobin (Std. β-coeff. – 0.04, p = 0.01), however, only in individuals without diabetes. We found no associations between plasma marine n-3 PUFA levels and fasting plasma glucose or carotid intima-media thickness. High levels of plasma marine n-3 PUFAs were associated with higher educational level, more physical activity and lower prevalence of smoking. Conclusion In this cross-sectional study of Norwegian individuals born in 1950, high levels of plasma marine n-3 PUFAs were favourably associated with several CV risk factors, suggesting that fish consumption might improve CV health.en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.ispartofseriesEuropean journal of nutrition;
dc.rightsAttribution 3.0 United States This is a post-peer-review, pre-copyedit version of an article published in European journal of nutrition. The final authenticated version is available online at: https://doi.org/10.1007/s00394-019-02007-3en
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.titlePlasma marine n-3 polyunsaturated fatty acids and cardiovascular risk factors: data from the ACE 1950 studyen
dc.typeJournal articleen
dc.typePeer revieweden
dc.description.versionacceptedVersionen
dc.identifier.doihttps://doi.org/10.1007/s00394-019-02007-3


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This is a post-peer-review, pre-copyedit version of an article published in European journal of nutrition. The final authenticated version is available online at: https://doi.org/10.1007/s00394-019-02007-3
Med mindre annet er angitt, så er denne innførselen lisensiert som Attribution 3.0 United States This is a post-peer-review, pre-copyedit version of an article published in European journal of nutrition. The final authenticated version is available online at: https://doi.org/10.1007/s00394-019-02007-3