Health status in subjects with suspected obstructive sleep apnea and comparison with a general population
The purpose of this study was to assess health status (HS) in patients with clinical suspicion of
obstructive sleep apnea (OSA) in order to estimate the dose response relationship between HS and
OSA severity, and to compare HS in this clinical cohort with a general population sample (N=5000).
Patients referred to an overnight sleep study due to suspected OSA, whom also responded to the SF-36
questionnaire, were included (N=418). Of these, 194 showed normal fndings, while 111, 60 and 53
demonstrated mild, moderate and severe OSA, respectively. Mean age was 47.5 (SD 11.9) and 69%
were males. Only the mental health scale (p=0.015) and mental component summary score (p=0.023)
were associated with OSA severity. This association, however, disappeared in multivariable analysis. All
SF-36 scores in the sleep study group were lower than that of the general population sample, in both
unadjusted and multivariable linear regression analysis. In this study, there was a lack of association
between OSA severity and general HS. However, as a whole, patients in this clinical population referred
to an overnight sleep study due to suspected OSA had impaired HS on all scales compared to a general
population, with greatest diferences in the vitality domain.