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dc.contributor.authorGrotle, Margreth
dc.contributor.authorHage, Kåre Birger
dc.contributor.authorNatvig, Bård
dc.contributor.authorDahl, Fredrik Andreas
dc.contributor.authorKvien, Tore Kristian
dc.date.accessioned2016-04-05T09:36:29Z
dc.date.available2016-04-05T09:36:29Z
dc.date.issued2008-10-02
dc.identifier.citationGrotle, M., Hagen, K. B., Natvig, B., Dahl, F. A., & Kvien, T. K. (2008). Obesity and osteoarthritis in knee, hip and/or hand: an epidemiological study in the general population with 10 years follow-up. BMC musculoskeletal disorders, 9(1), 1.en_US
dc.identifier.issn1471-2474
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2474-9-132
dc.identifier.urihttps://hdl.handle.net/10642/3214
dc.description.abstractBackground: Obesity is one of the most important risk factors for osteoarthritis (OA) in knee(s). However, the relationship between obesity and OA in hand(s) and hip(s) remains controversial and needs further investigation. The purpose of this study was to investigate the impact of obesity on incident osteoarthritis (OA) in hip, knee, and hand in a general population followed in 10 years. Methods: A total of 1854 people aged 24–76 years in 1994 participated in a Norwegian study on musculoskeletal pain in both 1994 and 2004. Participants with OA or rheumatoid arthritis in 1994 and those above 74 years in 1994 were excluded, leaving n = 1675 for the analyses. The main outcome measure was OA diagnosis at follow-up based on self-report. Obesity was defined by a body mass index (BMI) of 30 and above. Results: At 10-years follow-up the incidence rates were 5.8% (CI 4.3–7.3) for hip OA, 7.3% (CI 5.7–9.0) for knee OA, and 5.6% (CI 4.2–7.1) for hand OA. When adjusting for age, gender, work status and leisure time activities, a high BMI (> 30) was significantly associated with knee OA (OR 2.81; 95%CI 1.32–5.96), and a dose-response relationship was found for this association. Obesity was also significantly associated with hand OA (OR 2.59; 1.08–6.19), but not with hip OA (OR 1.11; 0.41–2.97). There was no statistically significant interaction effect between BMI and gender, age or any of the other confounding variables. Conclusion: A high BMI was significantly associated with knee OA and hand OA, but not with hip OA.en_US
dc.description.sponsorshipThe study was financed by the University of Oslo and the Trygve Gythfeldt fund.en_US
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.relation.ispartofseriesBMC Musculoskeletal Disorders;9(1)
dc.subjectObesityen_US
dc.subjectOsteoarthritisen_US
dc.subjectKneesen_US
dc.subjectHipsen_US
dc.subjectHandsen_US
dc.subjectEpidemiological studiesen_US
dc.subjectProspective studiesen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Reumatologi: 759en_US
dc.titleObesity and osteoarthritis in knee, hip and/or hand: An epidemiological study in the general population with 10 years follow-upen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.version© 2008 Grotle et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US


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