• Long-term follow-up of a hospital-based, multi-intervention programme in type 2 diabetes mellitus: impact on cardiovascular events and death 

      Ofstad, Anne Pernille; Ulimoen, Geir Reinvik; Orvik, Elsa; Birkeland, Kåre I; Gullestad, Lars; Fagerland, Morten; Johansen, Odd Erik (Journal of International Medical Research;45(5), Journal article; Peer reviewed, 2017-06-19)
      Objective To report the long-term impact on cardiovascular (CV) outcomes and mortality of a 2-year hospital-based multi-interventional care programme as compared with general practitioner (GP)-provided standard ...
    • No associations established between single nucleotide polymorphisms in human Toll-like receptor 2 and Toll-interacting protein and Staphylococcus aureus bloodstream infections 

      Smeland, Tor Eirik; Müller, Fredrik; Blomfeldt, Anita; Stavem, Knut; Aamot, Hege Vangstein (Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS);125(10), Journal article; Peer reviewed, 2017-07-24)
      Staphylococcus aureus bloodstream infections (SABSI) are associated with high morbidity and mortality. The Toll‐like receptor 2 (TLR2) and Toll‐interacting protein (TOLLIP) are important in recognition and regulation of ...
    • Noninvasive profiling of serum cytokines in breast cancer patients and clinicopathological characteristics 

      Jabeen, Shakila; Espinoza, Jaime; Torland, Lilly Anne; Zucknick, Manuela; Kumar, Surendra; Haakensen, Vilde Drageset; Luders, Torben; Engebraaten, Olav; Børresen-Dale, Anne-Lise; Kyte, Jon A.; Gromov, Pavel; Naume, Bjørn; Kristensen, Vessela N.; Gromova, Irina; Tekpli, Xavier (Oncoimmunology;8(2), Journal article; Peer reviewed, 2018-06-05)
      Cancers elicit an immune response by modifying the microenvironment. The immune system plays a pivotal role in cancer recognition and eradication. While the potential clinical value of infiltrating lymphocytes at the tumor ...
    • Norwegian patients and retail chicken meat share cephalosporin-resistant Escherichia coli and IncK/blaCMY-2 resistance plasmids 

      Berg, Einar Sverre; Wester, Astrid Lousie; Ahrenfeldt, J; Mo, Solveig Sølverød; Slettemeås, Jannice Schau; Steinbakk, Martin; Samuelsen, Ørjan; Grude, Nils; Simonsen, Gunnar Skov; Löhr, Iren Høyland; Jørgensen, Silje; Tofteland, Ståle; Lund, O; Dahle, Ulf R; Sunde, Marianne (Clinical microbiology and infection;23(6), Journal article; Peer reviewed, 2017-06)
      Objectives In 2012 and 2014 the Norwegian monitoring programme for antimicrobial resistance in the veterinary and food production sectors (NORM-VET) showed that 124 of a total of 406 samples (31%) of Norwegian retail ...
    • Peripheral arthritis in patients with long-term inflammatory bowel disease. Results from 20 years of follow-up in the IBSEN study 

      Ossum, Alvilde Maria; Palm, Øyvind; Småstuen, Milada Cvancarova; Solberg, Inger Camilla; Vatn, Morten H; Moum, Bjørn; Høivik, Marte Lie (Scandinavian Journal of Gastroenterology;53(10-11), Journal article; Peer reviewed, 2018-10-24)
      Objectives: Peripheral arthritis and related musculoskeletal manifestations, often classified as peripheral spondyloarthritis, are frequently seen in patients with inflammatory bowel disease (IBD). Few long-term studies ...
    • Serum cytokine levels in breast cancer patients during neoadjuvant treatment with bevacizumab 

      Jabeen, Shakila; Zucknick, Karola Manuela; Nome, Marianne Eikhom; Dannenfelser, Ruth; Fleischer, Thomas; Kumar, Surendra; Luders, Torben; Gythfeldt, Hedda; Troyanskya, Olga; Kyte, Jon A.; Børresen-Dale, Anne-Lise; Naume, Bjørn; Tekpli, Xavier; Engebråten, Olav; Kristensen, Vessela N. (Oncoimmunology;7(11), Journal article; Peer reviewed, 2018-01-08)
      A high concentration of circulating vascular endothelial growth factor (VEGF) in cancer patients is associated with an aggressive tumor phenotype. Here, serum levels of 27 cytokines and blood cell counts were assessed in ...
    • Somatic EP300-G211S mutations are associated with overall somatic mutational patterns and breast cancer specific survival in triple-negative breast cancer 

      Bemanian, Vahid; Noone, John Cristopher; Sauer, Torill; Touma, Joel Joul; Vetvik, Katja K.; Söderberg-Naucler, Cecilia; Lindstrøm, Jonas Christoffer; Bukholm, Ida Rashida Khan; Kristensen, Vessela N.; Geisler, Jürgen (Breast cancer research and treatment;172(2), Journal article; Peer reviewed, 2018-08-21)
      Purpose We have compared the mutational profiles of human breast cancer tumor samples belonging to all major subgroups with special emphasis on triple-negative breast cancer (TNBC). Our major goal was to identify specific ...
    • A survey of the clinicopathological and molecular characteristics of patients with suspected Lynch syndrome in Latin America 

      Rossi, Benedito Mauro; Palmero, Edenir Inêz; López-Kostner, Francisco; Sarroca, Carlos; Vaccaro, Carlos Alberto; Spirandelli, Florencia; Ashton-Prolla, Patricia; Rodriguez, Yenni; Galvão, Henrique de Campos Reis; Reis, Rui Manuel; dePaula, André Escremim; Romagnolo, Luis Gustavo Capochin; Alvarez, Karin; Valle, Adriana Della; Neffa, Florencia; Kalfayan, Pablo German; Spirandelli, Enrique; Chialina, Sergio; Angulo, Melva Gutiérrez; Castro-Mujica, Maria del Carmen; de Monte, Julio Sanchez; Quispe, Richard; de Silva, Sabrina Daniela; Rossi, Norma Teresa; Barletta-Carrillo, Claudia; Revollo, Susann; Taborga, Ximena; Morillas, L. Lena; Tubeuf, Hélène; Monteiro-Santos, Erika Maria; Piñero, Tamara Alejandra; Dominguez-Barrera, Constantino; Wernhoff, Patrik; Martins, Alexandra; Hovig, Eivind; Møller, Pål; Valentin, Mev Dominguez (BMC cancer;17(1), Journal article; Peer reviewed, 2017-09-05)
      Background Genetic counselling and testing for Lynch syndrome (LS) have recently been introduced in several Latin America countries. We aimed to characterize the clinical, molecular and mismatch repair (MMR) variants ...
    • Time series analysis of neoadjuvant chemotherapy and bevacizumab-treated breast carcinomas reveals a systemic shift in genomic aberrations 

      Møller, Elen Kristine; Nord, Silje; Wedge, David C.; Lingjærde, Ole Christian; Silwal-Pandit, Laxmi; Gythfeldt, Hedda; Vollan, Hans Kristian Moen; Fleischer, Thomas; Krohn, Marit; Schlichting, Ellen; Borgen, Elin; Garred, Øystein; Holmen, Marit Muri; Wist, Erik; Naume, Bjørn; Van Loo, Peter; Børresen-Dale, Anne-Lise; Engebråten, Olav; Kristensen, Vessela N. (Genome medicine;10(1), Journal article; Peer reviewed, 2018-11-29)
      Background Chemotherapeutic agents such as anthracyclines and taxanes are commonly used in the neoadjuvant setting. Bevacizumab is an antibody which binds to vascular endothelial growth factor A (VEGFA) and inhibits its ...
    • Tumor-associated macrophages are strongly related to vascular invasion, non-luminal subtypes, and interval breast cancer 

      Klingen, Tor Audun; Chen, Ying; Aas, Hans; Wik, Elisabeth; Akslen, Lars A (Human Pathology;69, Journal article; Peer reviewed, 2017-11)
      Tumor-associated macrophages (TAM) resemble M2 macrophages, promote tumor invasion and show strong expression of CD163 in breast cancer. We here investigated the association between CD163-positive macrophages and vascular ...
    • The Valgent4 protocol: Robust analytical and clinical validation of 11 HPV assays with genotyping on cervical samples collected in SurePath medium 

      Bonde, Jesper; Ejegod, Ditte Møller; Cuschieri, Kate; Dillner, Joakim; Heideman, Daniëlle A. M.; Quint, Wim; Ribas, Miguel Angel pavon; Padalko, Elizaveta; Christiansen, Irene Kraus; Xu, Lan; Arbyn, Marc (Journal of Clinical Virology;108, Journal article; Peer reviewed, 2018-09-14)
      Background The VALidation of HPV GENoyping Tests (VALGENT) is an international initiative designed to validate HPV assays with genotyping capability. The VALGENT4 protocol differs from previous VALGENT installments as the ...