Akershus Universitetssykehus HF: Nye registreringer
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Epidemiology of distal radius fracture in Akershus, Norway, in 2010-2011
(Journal of orthopaedic surgery and research;13(1), Journal article; Peer reviewed, 2018-08-13)Background Several studies published over the last decade indicate an increased incidence of distal radius fractures (DRF). With Norway having one of the highest reported incidence of DRFs, we conducted a study to assess ... -
Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis
(Journal of hepatology;66(6), Journal article; Peer reviewed, 2017-02-02)Background & Aims Prognostic biomarkers are lacking in primary sclerosing cholangitis, hampering patient care and the development of therapy. We aimed to identify novel protein biomarkers of disease severity and prognosis ... -
B-cell composition in the blood and cerebrospinal fluid of multiple sclerosis patients treated with dimethyl fumarate
(Multiple sclerosis and related disorders;26, Journal article; Peer reviewed, 2018-08-30)Background:B cells may contribute to the immunopathogenesis of multiple sclerosis (MS). Dimethyl fumarate(DMF) has recently been shown to reduce the frequency of memory B cells in blood, but it is not known whetherthe drug ... -
Initial Phase NT-proBNP, but Not Copeptin and High-Sensitivity Cardiac Troponin-T Yielded Diagnostic and Prognostic Information in Addition to Clinical Assessment of Out-of-Hospital Cardiac Arrest Patients With Documented Ventricular Fibrillation
(Frontiers in cardiovascular medicine;5, Journal article; Peer reviewed, 2018-06-07)Aim: Sudden cardiac arrest (SCA) secondary to ventricular fibrillation (VF) may be due to different cardiac conditions. We investigated whether copeptin, hs-cTnT and NT-proBNP in addition to clinical assessment may help ... -
Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin: Educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB)
(Clinical Chemistry and Laboratory Medicine (CCLM);57(5), Journal article; Peer reviewed, 2018-06-10)Two interferences recently brought to the forefront as patient safety issues include hemolysis (hemoglobin) and biotin (vitamin B7). The International Federation for Clinical Chemistry Committee on Cardiac Biomarkers ... -
Trajectories of Depression in Late Life: A 1-Year Follow-Up Study
(Dementia and geriatric cognitive disorders;43(3-4), Journal article; Peer reviewed, 2017-04)Aims: To investigate the prognosis of depression in late life (DLL) in terms of the course of depression over 1 year and assess clinical factors related to the prognosis. Methods: We performed an observational, multicenter, ... -
Searching for ‘transformative moments’: a qualitative study of nurses’ work during home visits to COPD patients and their caregivers in Norway
(Nursing Open;6(2), Journal article; Peer reviewed, 2018-10-09)Aim The integration of families into healthcare services is being emphasized increasingly in healthcare polices. The aim of this study was to investigate how professionals during home visits support both patients and ... -
Balloon eustachian tuboplasty: Systematic review of long-term outcomes and proposed indications
(The journal of international advanced otology;14(1), Journal article; Peer reviewed, 2018-04)Balloon Eustachian tuboplasty (BET) aims to improve the function of the Eustachian tube (ET). The objective of this study was to review the longterm outcome of BET and present the process and results of outlining indications ... -
Cognitive behavior therapy for child and adolescent anxiety disorders: an update on recent evidence
(Current opinion in psychiatry;31(6), Journal article; Peer reviewed, 2018-11-01)Purpose of review To present an updated review of recent studies into the effect of cognitive behavior therapy (CBT) for anxiety disorders in children and adolescents, ways to increase access to therapy, and predictors and ... -
Trolly dilemmas fail to predict ethical judgment in a hypothetical vaccination context
(Journal of Empirical Research on Human Research Ethics;14(1), Journal article; Peer reviewed, 2018-11-01)We investigated whether the responses of 68 ethics committee members and staff to trolley dilemmas could predict their responses to research ethics problems concerning vaccine trials. Trolley dilemmas deal with the issue ... -
Somatic EP300-G211S mutations are associated with overall somatic mutational patterns and breast cancer specific survival in triple-negative breast cancer
(Breast cancer research and treatment;172(2), Journal article; Peer reviewed, 2018-08-21)Purpose We have compared the mutational profiles of human breast cancer tumor samples belonging to all major subgroups with special emphasis on triple-negative breast cancer (TNBC). Our major goal was to identify specific ... -
Respiratory pump maintains cardiac stroke volume during hypovolemia in young, healthy volunteers
(Journal of Applied Physiology;124(5), Journal article; Peer reviewed, 2018-05-24)Abstract Spontaneous breathing has beneficial effects on the circulation, since negative intrathoracic pressure enhances venous return and increases cardiac stroke volume. We quantified the contribution of the respiratory ... -
Cognitive-behavioral therapy for youth anxiety: An effectiveness evaluation in community practice
(Journal of consulting and clinical psychology;86(9), Journal article; Peer reviewed, 2018-09)Objective: To compare the effectiveness of individual cognitive–behavioral therapy (ICBT) and group CBT (GCBT) for referred children with anxiety disorders within community mental health clinics. Method: Children (N = 165; ... -
Novel biomarkers of cardiovascular disease: Applications in clinical practice
(Critical reviews in clinical laboratory sciences;56(1), Journal article; Peer reviewed, 2018-11-20)Measurement of biomarkers has revolutionized the work-up of patients with suspected cardiovascular disease. The most widely used contemporary cardiovascular biomarkers are the natriuretic peptides in the diagnosis and ... -
The Valgent4 protocol: Robust analytical and clinical validation of 11 HPV assays with genotyping on cervical samples collected in SurePath medium
(Journal of Clinical Virology;108, Journal article; Peer reviewed, 2018-09-14)Background The VALidation of HPV GENoyping Tests (VALGENT) is an international initiative designed to validate HPV assays with genotyping capability. The VALGENT4 protocol differs from previous VALGENT installments as the ... -
The possible impact of vulnerability on clinical communication: Some reflections and a call for empirical studies
(Patient education and counseling;101(11), Journal article; Peer reviewed, 2018-07-30)Objective To direct attention to the concept of vulnerability, how it affects interactions in subtle ways and is difficult to detect in studies of clinical dialogues. Methods A reflection on three everyday examples ... -
Acute uncomplicated diverticulitis managed without antibiotics – difficult to introduce a new treatment protocol but few complications
(Scandinavian journal of gastroenterology;54(1), Journal article; Peer reviewed, 2019-01-16)Objective: Routine antibiotic treatment of acute uncomplicated diverticulitis (AUD) has been shown ineffective. In this study, the adherence to a new treatment protocol for uncomplicated diverticulitis was evaluated and ... -
Inflammation and Mechanical Stress Stimulate Osteogenic Differentiation of Human Aortic Valve Interstitial Cells
(Frontiers in physiology;9, Journal article; Peer reviewed, 2018-11-20)Background: Aortic valve calcification is an active proliferative process, where interstitial cells of the valve transform into either myofibroblasts or osteoblast-like cells causing valve deformation, thickening of cusps ... -
Time series analysis of neoadjuvant chemotherapy and bevacizumab-treated breast carcinomas reveals a systemic shift in genomic aberrations
(Genome medicine;10(1), Journal article; Peer reviewed, 2018-11-29)Background Chemotherapeutic agents such as anthracyclines and taxanes are commonly used in the neoadjuvant setting. Bevacizumab is an antibody which binds to vascular endothelial growth factor A (VEGFA) and inhibits its ... -
Vertebral Bone Mineral Density Measured by Quantitative Computed Tomography With and Without a Calibration Phantom: A Comparison Between 2 Different Software Solutions
(Journal of Clinical Densitometry;21(3), Journal article; Peer reviewed, 2018-03-27)Quantitative computed tomography (CT) can be used to quantify bone mineral density (BMD) in the spine from clinical CT scans. We aimed to determine agreement and precision of BMD measurements by 2 different methods: ...