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Two novel connexin32 mutations cause early onset X-linked Charcot-Marie-Tooth disease
(BioMed Central, 2007-07-09)
Background
X-linked Charcot-Marie Tooth (CMT) is caused by mutations in the connexin32 gene that encodes a polypeptide which is arranged in hexameric array and form gap junctions.
Methods
We describe two novel ...
Physical distress is associated with cardiovascular events in a high
(BioMed Central, 2009-03-30)
Background: Self-reported health perceptions such as physical distress and quality of life are
suggested independent predictors of mortality and morbidity in patients with established
cardiovascular disease. This study ...
Obesity and osteoarthritis in knee, hip and/or hand: An epidemiological study in the general population with 10 years follow-up
(BioMed Central, 2008-10-02)
Background: Obesity is one of the most important risk factors for osteoarthritis (OA) in knee(s).
However, the relationship between obesity and OA in hand(s) and hip(s) remains controversial and
needs further investigation. ...
An update on cladribine for relapsing-remitting multiple sclerosis
(Taylor & Francis, 2017-09-11)
INTRODUCTION: Despite recent progress, currently available therapies for relapsing remitting multiple sclerosis (MS) are only partly effective, and their use is limited by tolerability and safety issues, as well as high ...
General population norms for the EQ-5D-3 L in Norway: comparison of postal and web surveys
(BMC Springer, 2018-10-19)
Background
The EQ-5D-3 L instrument is a standardized questionnaire which was developed as a simple, generic measure of health for clinical and economic appraisal. To aid in the interpretation, scores are often compared ...
Anxiety, Family Functioning and Neuroendocrine Biomarkers in Obese Children
(Centro Editor Livreiro da Ordem dos Médicos, Socie, 2017-04-30)
Introduction: This observational study explores potential links between obese children’s cortisol, and parental mental state, family
functioning, and the children’s symptoms of anxiety and depression.
Material and Methods: ...
Policy responses to hepatitis C in the Nordic countries: Gaps and discrepant reporting in the Hep-Nordic study
(PLOS, 2018-01-30)
Background and aims
In the Nordic countries (Denmark, Finland, Iceland, Norway, Sweden), the prevalence of chronic hepatitis C virus (HCV) infection is relatively low in the general population, but is much higher among ...
A review of oxygen use during chest compressions in Newborns-A meta-analysis of animal data
(Frontiers Media S.A., 2018-12-18)
Background: International consensus statements for resuscitation of newborn infants recommend provision of 100% oxygen once chest compressions are required. However, 100% oxygen exacerbates reperfusion injury and reduces ...
Patient safety culture in out-of-hours primary care services in the Netherlands: a cross-sectional survey
(Taylor & Francis, 2018-01-15)
Objective: To examine patient safety culture in Dutch out-of-hours primary care using the safety attitudes questionnaire (SAQ) which includes five factors: teamwork climate, safety climate, job satisfaction, perceptions ...
Activated prothrombin complex concentrate to reverse the factor Xa inhibitor (apixaban) effect before emergency surgery: A case series
(BMC Springer, 2018-05-16)
Background
The lack of an antidote against factor Xa inhibitors in case of major bleeding or need for urgent surgery is a concern to clinicians. Guidelines on managing major bleeding in patients under anticoagulation with ...