The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study
Sideli, Lucia; Aas, Monica; Quattrone, Diego; La Barbera, Daniele; La Cascia, Caterina; Ferraro, Laura; Alameda, Luis; Velthorst, Eva; Trotta, Giulia; Tripoli, Giada; Schimmenti, Adriano; Fontana, Andrea; Gayer-Anderson, Charlotte; Stilo, Simona; Seminerio, Fabio; Sartorio, Crocettarachele; Marrazzo, Giovanna; Lasalvia, Antonio; Tosato, Sarah; Tarricone, Ilaria; Berardi, Domenico; D’Andrea, Giuseppe; Arango, Celso; Arrojo, Manuel; Bernardo, Miguel; Bobes, Julio; Sanjuán, Julio; Santos, Jose Luis; Menezes, Paulo Rossi; Del-Ben, Cristina Marta; Jongsma, Hannah E.; Jones, Peter B; Kirkbride, James B.; Llorca, Pierre-Michel; Tortelli, Andrea; Pignon, Baptiste; De Haan, Lieuwe; Selten, Jean-Paul; Van Os, Jim; Rutten, Bart P; Bentall, Richard; Di Forti, Marta; Murray, Robin M.; Morgan, Craig; Fisher, Helen L.
Peer reviewed, Journal article
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https://hdl.handle.net/11250/3110657Utgivelsesdato
2023Metadata
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Originalversjon
Social Psychiatry and Psychiatric Epidemiology. 2023, 58 1573-1580. 10.1007/s00127-023-02513-0Sammendrag
This study investigated if the association between childhood maltreatment and cognition among psychosis patients and com-
munity controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755)
and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient
(IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS
did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these
expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.