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dc.contributor.authorPham, Uyen Ha Gia
dc.contributor.authorSkogseid, Inger Marie
dc.contributor.authorPripp, Are Hugo
dc.contributor.authorBøen, Erlend
dc.contributor.authorToft, Mathias
dc.date.accessioned2021-11-04T14:53:31Z
dc.date.available2021-11-04T14:53:31Z
dc.date.created2021-10-22T09:06:39Z
dc.date.issued2021-03-12
dc.identifier.citationPLOS ONE. 2021, 16 (3), 1-13.en_US
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/11250/2827969
dc.description.abstractBackground: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a recognized treatment in Parkinson’s disease (PD). Knowledge is still limited regarding the possible impact of STN-DBS on personality traits and the personality characteristics of PD patients who undergo surgery. Methods: To assess personality traits in relation to STN-DBS we did an ancillary protocol as part of a prospective randomized study that compared two surgical strategies. Patients were assessed with the Temperament and Character Inventory (TCI), the Urgency, Premeditation, Perseverance and Sensation Seeking impulse behavior scale, the Eysenck Personality Questionnaire (EPQ) and the Toronto Alexithymia Scale preoperatively and after one year of STN-DBS. EPQ and TCI baseline scores were compared with mean scores of healthy reference populations. Results: After 12-months of STN-DBS, there was a significant decline in Persistence compared to baseline. Preoperatively, the STN-DBS patients had significantly lower Persistence and Self-Transcendence scores, and significantly higher scores on Novelty-Seeking, Self-Directedness, Cooperativeness and on Social Conformity than referenced populations. No difference was found in Neuroticism or Harm-Avoidance scores. The baseline prevalence of alexithymia was low and at 1-year follow-up there was no significant change in alexithymia scores. Conclusions: We found a higher baseline level of impulsivity in PD patients who underwent STN-DBS. After one year of STN-DBS, our results indicated that the treatment may affect the patients’ personality by increasing certain aspects of impulsivity. There was no effect on alexithymia. The preoperative personality profile of PD patients might influence the outcome of STN-DBS.en_US
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofseriesPLOS ONE;16(3): e0248568
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.subjectParkinson diseaseen_US
dc.subjectPersonality traitsen_US
dc.subjectImpulsivityen_US
dc.subjectPersonalitiesen_US
dc.subjectMedical proceduresen_US
dc.subjectDopaminergicsen_US
dc.subjectBehaviorsen_US
dc.titleImpulsivity in Parkinson’s disease patients treated with subthalamic nucleus deep brain stimulation—An exploratory studyen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2021 Pham et al.en_US
dc.source.articlenumbere0248568en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0248568
dc.identifier.cristin1947748
dc.source.journalPLOS ONEen_US
dc.source.volume16en_US
dc.source.issue3en_US
dc.source.pagenumber1-13en_US


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal