dc.contributor.author | Hilde, Janne Mykland | |
dc.contributor.author | Hisdal, Jonny | |
dc.contributor.author | Skjørten, Ingunn | |
dc.contributor.author | Hansteen, Viggo | |
dc.contributor.author | Melsom, Morten Nissen | |
dc.contributor.author | Grøtta, Ole Jørgen | |
dc.contributor.author | Småstuen, Milada Cvancarova | |
dc.contributor.author | Seljeflot, Ingebjørg | |
dc.contributor.author | Arnesen, Harald | |
dc.contributor.author | Hummerfeldt, Sjur | |
dc.contributor.author | Steine, Kjetil | |
dc.date.accessioned | 2021-01-28T09:10:49Z | |
dc.date.accessioned | 2021-03-05T08:40:12Z | |
dc.date.available | 2021-01-28T09:10:49Z | |
dc.date.available | 2021-03-05T08:40:12Z | |
dc.date.issued | 2020-07-16 | |
dc.identifier.citation | Hilde, Hisdal, Skjørten, Hansteen, Melsom, Grøtta, Småstuen, Seljeflot, Arnesen, Hummerfeldt S, Steine. Left ventricular dysfunction in COPD without pulmonary hypertension. PLOS ONE. 2020;15(7) | en |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | https://hdl.handle.net/10642/9875 | |
dc.description.abstract | Objectives: We aimed to assess prevalence of left ventricular (LV) systolic and diastolic function in stable cohort of COPD patients, where LV disease had been thoroughly excluded in advance. Methods: 100 COPD outpatients in GOLD II-IV and 34 controls were included. Patients were divided by invasive mean pulmonary artery pressure (mPAP) in COPD-PH (≥25 mmHg) and COPD-non-PH (<25 mmHg), which was subdivided in mPAP ≤20 mmHg and 21–24 mmHg. LV myocardial performance index (LV MPI) and strain by tissue Doppler imaging (TDI) were used for evaluation of LV global and systolic function, respectively. LV MPI ≥0.51 and strain ≤-15.8% were considered abnormal. LV diastolic function was assessed by the ratio between peak early (E) and late (A) velocity, early TDI E´, E/E´, isovolumic relaxation time, and left atrium volume. Results: LV MPI ≥0.51 was found in 64.9% and 88.5% and LV strain ≤-15.8% in 62.2.% and 76.9% in the COPD-non-PH and COPD-PH patients, respectively. Similarly, LV MPI and LV strain were impaired even in patients with mPAP <20 mmHg. In multiple regression analyses, residual volume and stroke volume were best associated to LV MPI and LV strain, respectively. Except for isovolumic relaxation time, standard diastolic echo indices as E/A, E´, E/E´ and left atrium volume did not change from normal individuals to COPD-non-PH. Conclusions: Subclinical LV systolic dysfunction was a frequent finding in this cohort of COPD patients, even in those with normal pulmonary artery pressure. Evidence of LV diastolic dysfunction was hardly present as measured by conventional echo indices. | en |
dc.description.sponsorship | JMH: Eastern Norway Regional Health Authority, 2303 Hamar. | en |
dc.language.iso | en | en |
dc.publisher | Public Library of Science | en |
dc.relation.ispartofseries | PLoS ONE;Volume 15, no 7 | |
dc.rights | Creative Commons Attribution 4.0 International (CC BY 4.0) License | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Myocardial performance indexes | en |
dc.subject | Chronic obstructive pulmonary diseases | en |
dc.subject | Systolic dysfunction | en |
dc.subject | Patients | en |
dc.subject | Relaxation times | |
dc.subject | Pulmonary hypertension | |
dc.subject | Heart rates | |
dc.subject | Blood pressure | |
dc.title | Left ventricular dysfunction in COPD without pulmonary hypertension | en |
dc.type | Journal article | en |
dc.type | Peer reviewed | en |
dc.date.updated | 2021-01-28T09:10:49Z | |
dc.description.version | publishedVersion | en |
dc.identifier.doi | https://doi.org/10.1371/journal.pone.0235075 | |
dc.identifier.cristin | 1821936 | |
dc.source.journal | PLOS ONE | |