Body weight, body composition and survival after 1 year: follow-up of a nutritional intervention trial in allo-HSCT recipients
dc.contributor.author | Skaarud, Kristin Aneta Joan | |
dc.contributor.author | Veierød, Marit Bragelien | |
dc.contributor.author | Lergenmuller, Simon | |
dc.contributor.author | Bye, Asta | |
dc.contributor.author | Iversen, Per Ole | |
dc.contributor.author | Tjønnfjord, Geir Erland | |
dc.date.accessioned | 2019-11-05T10:43:02Z | |
dc.date.accessioned | 2019-11-07T13:30:33Z | |
dc.date.available | 2019-11-05T10:43:02Z | |
dc.date.available | 2019-11-07T13:30:33Z | |
dc.date.issued | 2019-07-21 | |
dc.identifier.citation | Skaarud KAJ, Veierød MB, Lergenmuller S, Bye A, Iversen PO, Tjønnfjord GE. Body weight, body composition and survival after 1 year: follow-up of a nutritional intervention trial in allo-HSCT recipients. Bone Marrow Transplantation. 2019 | en |
dc.identifier.issn | 0268-3369 | |
dc.identifier.issn | 0268-3369 | |
dc.identifier.issn | 1476-5365 | |
dc.identifier.uri | https://hdl.handle.net/10642/7804 | |
dc.description.abstract | The role of body weight change in survival among recipients of hematopoietic stem-cell transplantation is controversial. We assessed the effect of optimizing energy and protein intake on 1-year survival, body weight and body composition, and the effect of body weight and body composition on 1-year survival in 117 patients (57 intervention, 60 control) in a randomized controlled trial. Cox regression was used to study effects of the intervention, weight and body composition on death, relapse, and nonrelapse mortality (NRM). We found no significant effect of intervention versus control on death hazard ratio (HR) 1.05, 95% confidence interval (CI) 0.54−2.04, p = 0.88), relapse (HR 1.15, 95% CI 0.48−2.27, p = 0.75), and NRM (HR 0.95, 95% CI 0.39−2.28, p = 0.90). Body weight, fat-free mass index, body fat mass index and total body water changed over time (p < 0.001), similarly in both groups (0.17 ≤ p ≤ 0.98). In multivariable analyses adjusted for group, gender and age, HRs and 95% CIs per one kilo increase in weight were 1.03 (1.01−1.06) and 1.04 (1.01−1.08) for death and NRM after 1 year (p ≤ 0.02), respectively, and 1.08 (1.01−1.15) for relapse after 3 months (p = 0.02). In conclusion, weight gain is possibly due to fluid retention and is an indicator of a complication in HSCT, rather than a marker of improved nutritional status. | en |
dc.description.sponsorship | The study was supported by Oslo University Hospital and the Throne Holst Foundation, Norway. SL was supported by a grant from the Institute of Basic Medical Sciences, University of Oslo, Norway. | en |
dc.language.iso | en | en |
dc.publisher | Springer Natue | en |
dc.relation.ispartofseries | Bone Marrow Transplantation;Published 27 August 2019 | |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Hematopoietic stem cell transplantations | en |
dc.subject | Body weight | en |
dc.subject | Body compositions | en |
dc.subject | Survival | en |
dc.title | Body weight, body composition and survival after 1 year: follow-up of a nutritional intervention trial in allo-HSCT recipients | en |
dc.type | Journal article | en |
dc.type | Peer reviewed | en |
dc.date.updated | 2019-11-05T10:43:02Z | |
dc.description.version | publishedVersion | en |
dc.identifier.doi | https://dx.doi.org/10.1038/s41409-019-0638-6 | |
dc.identifier.cristin | 1712284 | |
dc.source.journal | Bone Marrow Transplantation |
Tilhørende fil(er)
Denne innførselen finnes i følgende samling(er)
-
HV - Institutt for sykepleie og helsefremmende arbeid [1386]
HV - Department of Nursing and Health Promotion
Med mindre annet er angitt, så er denne innførselen lisensiert som This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.