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dc.contributor.authorEskild, Anne
dc.contributor.authorMonkerud, Lars Chr.
dc.contributor.authorJukic, Anne Marie Z.
dc.contributor.authorÅsvold, Bjørn Olav
dc.contributor.authorLie, Kari Helene Elise Kveim
dc.date.accessioned2019-02-25T10:09:39Z
dc.date.accessioned2019-04-04T07:59:59Z
dc.date.available2019-02-25T10:09:39Z
dc.date.available2019-04-04T07:59:59Z
dc.date.issued2018-07-04
dc.identifier.citationEskild A, Monkerud LC, Jukic AMZ, Åsvold BO, Lie KK. Maternal concentrations of human chorionic gonadotropin (hCG) and risk for cerebral palsy (CP) in the child. A case control study. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2018;228:203-208en
dc.identifier.issn0301-2115
dc.identifier.issn0301-2115
dc.identifier.issn1872-7654
dc.identifier.urihttps://hdl.handle.net/10642/6918
dc.description.abstractBackground Intrauterine conditions may be important in the development of cerebral palsy in the child. The hormone, human chorionic gonadotropin (hCG), is synthesized in the placenta, and hCG plays an important role in placental angiogenesis and development. Thus, maternal hCG concentrations may be an indicator of placental function and thereby the intrauterine environment for the offspring. We studied the associations of maternal concentrations of hCG during pregnancy with cerebral palsy in the child. Methods We performed a case-control study nested within a cohort of 29,948 pregnancies in Norway during 1992–1994. Cases were all women within the cohort who gave birth to a singleton child with cerebral palsy diagnosed before five years of age (n = 63). Controls were a random sample of women with a singleton child without cerebral palsy (n = 182). Results The adjusted odds ratio (OR) for cerebral palsyin the child was 0.78 (95% CI: 0.55–1.10) per log-transformed unit of maternal hCG in the 1 st trimester, and the OR was 1.42 (95% CI: 0.94–2.16) in the 2nd trimester. Thus, women who did not have high hCG concentrations in the 1 st trimester and low hCG concentrations in the 2nd trimester, had increased risk for giving birth to a child with cerebral palsy. Adjustments were made for pregnancy week of serum sampling, maternal age and parity. Conclusions The abnormal hCG concentrations in pregnancies with cerebral palsy in the offspring, could suggest placental factors as causes of cerebral palsy.en
dc.description.sponsorshipThe data collection was funded by Norwegian Institute of Public Health. Data analyses was supported in part by a grant from Akeshus University Hopsital, Norway (Grant number 266902), and reporting was supported by the Eunice Kennedy Shriver National Institute of Child Health, and Human Development of the National Institutes of Health (NIH) under award number (R00HD079659) for the author A.M.J.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.ispartofseriesEuropean Journal of Obstetrics and Gynecology and Reproductive Biology;Volume 228
dc.rights© 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectHuman chorionic gonadotropinen
dc.subjectCerebral palsyen
dc.subjectPregnancyen
dc.subjectRisk factorsen
dc.titleMaternal concentrations of human chorionic gonadotropin (hCG) and risk for cerebral palsy (CP) in the child. A case control studyen
dc.typeJournal articleen
dc.typePeer revieweden
dc.date.updated2019-02-25T10:09:39Z
dc.description.versionpublishedVersionen
dc.identifier.doihttps://dx.doi.org/10.1016/j.ejogrb.2018.07.003
dc.identifier.cristin1613221
dc.source.journalEuropean Journal of Obstetrics, Gynecology, and Reproductive Biology


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© 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND
license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Except where otherwise noted, this item's license is described as © 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).