Maternal history of miscarriages and measures of fertility in relation to childhood asthma
dc.contributor.author | Magnus, Maria Christine | |
dc.contributor.author | Karlstad, Øystein | |
dc.contributor.author | Parr, Christine Louise | |
dc.contributor.author | Page, Christian | |
dc.contributor.author | Nafstad, Per | |
dc.contributor.author | Magnus, Per | |
dc.contributor.author | London, Stephanie J | |
dc.contributor.author | Wilcox, Allen J | |
dc.contributor.author | Nystad, Wenche | |
dc.contributor.author | Håberg, Siri Eldevik | |
dc.date.accessioned | 2018-12-11T12:24:33Z | |
dc.date.accessioned | 2019-01-04T13:07:16Z | |
dc.date.available | 2018-12-11T12:24:33Z | |
dc.date.available | 2019-01-04T13:07:16Z | |
dc.date.issued | 2018-12-04 | |
dc.identifier.citation | Magnus MC, Karlstad Ø, Parr CL, Page CM, Nafstad P, Magnus P, London SJ, Wilcox AJ, Nystad W, Håberg SE. Maternal history of miscarriages and measures of fertility in relation to childhood asthma. Thorax. 2018 | en |
dc.identifier.issn | 0040-6376 | |
dc.identifier.issn | 0040-6376 | |
dc.identifier.issn | 1468-3296 | |
dc.identifier.uri | https://hdl.handle.net/10642/6460 | |
dc.description.abstract | Background: it remains unclear what underlies the greater risk of asthma reported among children conceived by assisted reproductive technologies (art). Objective: Our aim was to clarify the role of parental subfertility and unmeasured confounding on the association between art and childhood asthma, and to examine the possibility for common mechanisms underlying parental subfertility and miscarriages influencing asthma pathogenesis. Methods: We used data from national norwegian health registries (n=474 402) and the norwegian Mother and child cohort Study (MoBa) (n=75 797). We used log-linear regression to estimate overall associations, and fixed-effects logistic regression to estimate associations within siblings. Results: ART offspring had greater asthma risk, the adjusted relative risk (arr) was 1.20 (95% ci 1.09 to 1.32) in the registry-based cohort, and 1.42 (95% ci 1.14 to 1.76) in MoBa. the sibling analysis yielded similar associations, although the ci included the null value. the elevated asthma risk among art offspring was attenuated when they were compared with spontaneously conceived offspring with time to conception >12 months, arr 1.22 (95% ci 0.95 to 1.57). asthma risk also increased with maternal history of early miscarriages (≤12 weeks), with an arr of 1.07 (95% ci 1.03 to 1.11) for one, arr 1.18 (95% ci 1.10 to 1.26) for two and arr 1.24 (95% ci 1.12 to 1.37) for three or more. Conclusion: Our findings indicate that both parental subfertility and characteristics related to the art procedure itself might increase offspring asthma risk, although this needs to be confirmed in future studies, and further suggest that common mechanisms underlying parental subfertility and recurrent miscarriages might influence offspring asthma pathogenesis. | en |
dc.description.sponsorship | The data collection in the Norwegian Mother and Child Cohort Study is supported by the National Institutes of Health (National Institute of Environmental Health Sciences contract number n01-eS-75558, National Institute of Neurological Disorders and Stroke grant no. 1 UO1 nS 047537-01 and grant no. 2 UO1 nS 047537-06a1) and the Norwegian Research Council (grant number 151918/S10). MCM works at the MRC Integrative Epidemiology Unit at the University of Bristol, which receives infrastructure funding from UK Medical Research Council (Mc/ UU/12013/5), and she is also supported by the fellowship from the UK Medical Research Council (Mr/M009351/1). AJW and SJl are both supported in part by the intramural Program of the National Institute of Environmental Health Sciences, NIH. this work was also supported by the Norwegian Research Council (grant no. 221919 to WN), and the Research Council of Norway Centres of Excellence funding scheme (project number 262700). | en |
dc.language.iso | en | en |
dc.publisher | BMJ Publishing Group | en |
dc.relation.ispartofseries | Thorax; Volume 74, Issue 2 | |
dc.relation.uri | https://thorax.bmj.com/content/thoraxjnl/early/2018/11/26/thoraxjnl-2018-211886.full.pdf | |
dc.rights | This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Miscarriages | en |
dc.subject | Fertility measures | en |
dc.subject | Childhood asthma | en |
dc.title | Maternal history of miscarriages and measures of fertility in relation to childhood asthma | en |
dc.type | Journal article | en |
dc.type | Peer reviewed | en |
dc.date.updated | 2018-12-11T12:24:33Z | |
dc.description.version | publishedVersion | en |
dc.identifier.doi | http://dx.doi.org/10.1136/thoraxjnl-2018-211886 | |
dc.identifier.cristin | 1641672 | |
dc.source.journal | Thorax |
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