Spatial navigation measured by the Floor Maze Test in patients with subjective cognitive impairment, mild cognitive impairment, and mild Alzheimer's disease
Tangen, Gro Gujord; Engedal, Knut; Bergland, Astrid; Moger, Tron Anders; Hansson, Oskar; Mengshoel, Anne Marit
Journal article, Peer reviewed
Åpne
Permanent lenke
https://hdl.handle.net/10642/3193Utgivelsesdato
2015-02-15Metadata
Vis full innførselSamlinger
Originalversjon
Tangen, G. G., Engedal, K., Bergland, A., Moger, T. A., Hansson, O., & Mengshoel, A. M. (2015). Spatial navigation measured by the Floor Maze Test in patients with subjective cognitive impairment, mild cognitive impairment, and mild Alzheimer's disease. Int Psychogeriatr, 1-9. http://dx.doi.org/10.1017/S1041610215000022Sammendrag
Background:Impaired spatial navigation is an early sign of Alzheimer disease (AD), but this can be difficult to assess in clinical practice. We examined how the performance on the Floor Maze Test (FMT), which combines navigation with walking, differed between patients with subjective cognitive impairment (SCI), mild cognitive impairment (MCI), and mild AD. We also explored if there was a significant relationshipbetween the FMT and the cognitive tests or sociodemographic factors.Methods:The study included 128 patients from a memory clinic classified as having SCI (n=19), MCI (n=20), and mild AD (n=89). Spatial navigation was assessed by having the patients walk through the FMT,a two-dimensional maze. Both timed measures and number of errors were recorded. Cognitive function was assessed bythe Word List Memory test, the Clock Drawing Test, the Trail Making Tests (TMT)A and B, andthe Mini Mental Status Examination (MMSE).Results:The patients with MCI were slowerthan thosewith SCI, while the patients with mild AD more frequently completed the FMT with errors or gave up than the patients with MCI. Performance on the FMT was significantly associated with executive function (measured by TMT‒B).Conclusions:The performances on the FMTworsened with increasing severity of cognitive impairment, and the FMT was primarily associated with executive function. The explained variance was relatively low, which may indicate that the standard cognitive test battery does not capture impairments of spatial navigation.
Utgiver
Cambridge University PressBeslektede innførsler
Viser innførsler beslektet ved tittel, forfatter og emneord.
-
Relationships between balance and cognition in patients with subjective cognitive impairment, mild cognitive impairment, and Alzheimer disease
Tangen, Gro Gujord; Engedal, Knut; Bergland, Astrid; Moger, Tron Anders; Mengshoel, Anne Marit (Physical therapy;94(8), Journal article; Peer reviewed, 2014-04-24)Background Balance impairments are common in patients with Alzheimer disease (AD), but which aspects of balance are affected, at which stage of cognitive impairment, and their associations with cognitive domains remain ... -
Biomarkers in subtypes of mild cognitive impairment and subjective cognitive decline
Eliassen, Carl F Andestad; Reinvang, Ivar; Selnes, Per; Grambaite, Ramune; Fladby, Tormod; Hessen, Erik (Brain and Behavior;7(9), Journal article; Peer reviewed, 2017-07-28)Objectives Preclinical Alzheimers disease (AD) patients may or may not show cognitive impairment on testing. AD biomarkers are central to the identification of those at low, intermediate, or high risk of later dementia ... -
Advantaged socioeconomic conditions in childhood are associated with higher cognitive functioning, but stronger cognitive decline in older age
Aartsen, Marja; Cheval, Boris; Sieber, Stefan; Van der Linden, Bernadette; Gabriel, Rainer; Courvoisier, Delphine S.; Guessous, Idris; Burton-Jeangros, Claudine; Blane, David; Ihle, Andreas; Kliegel, Matthias; Cullati, Stéphane (Proceedings of the National Academy of Sciences of the United States of America;Vol. 116, No. 12, Journal article; Peer reviewed, 2019-02-25)Cognitive aging is characterized by large heterogeneity, which may be due to variations in childhood socioeconomic conditions (CSC). Although there is substantial evidence for an effect of CSC on levels of cognitive ...