dc.contributor.author | Andersen, Jorunn Marie | en_US |
dc.contributor.author | Herning, Hilde | en_US |
dc.contributor.author | Aschim, Elin L. | en_US |
dc.contributor.author | Hjelmesæth, Jøran | en_US |
dc.contributor.author | Mala, Tom | en_US |
dc.contributor.author | Hanevik, Hans Ivar | en_US |
dc.contributor.author | Bungum, Mona | en_US |
dc.contributor.author | Haugen, Trine B. | en_US |
dc.contributor.author | Witczak, Oliwia | en_US |
dc.date.accessioned | 2015-09-21T11:16:19Z | |
dc.date.available | 2015-09-21T11:16:19Z | |
dc.date.issued | 2015-06-12 | en_US |
dc.identifier.citation | Andersen, J. M., Herning, H., Aschim, E. L., Hjelmesæth, J., Mala, T., Hanevik, H. I., ... & Witczak, O. (2015). Body Mass Index Is Associated with Impaired Semen Characteristics and Reduced Levels of Anti-Müllerian Hormone across a Wide Weight Range. PloS one, 10(6), e0130210. | en_US |
dc.identifier.issn | 1932-6203 | en_US |
dc.identifier.other | FRIDAID 1249926 | en_US |
dc.identifier.uri | https://hdl.handle.net/10642/2693 | |
dc.description.abstract | There is still controversy as to how body mass index (BMI) affects male reproduction. We investigated how BMI is associated with semen quality and reproductive hormones in 166 men, including 38 severely obese men. Standard semen analysis and sperm DNA integrity analysis were performed, and blood samples were analysed for reproductive hormones. Adjusted for age and time of abstinence, BMI was negatively associated with sperm concentration (B = -0.088, P = 0.009), total sperm count (B = -0.223, P = 0.001), progressive sperm motility (B = -0.675, P = 0.007), normal sperm morphology (B = -0.078, P = 0.001), and percentage of vital spermatozoa (B = -0.006, P = 0.027). A negative relationship was observed between BMI and total testosterone (B = -0.378, P < 0.001), sex hormone binding globulin (B = -0.572, P < 0.001), inhibin B (B = -3.120, P < 0.001) and anti-Müllerian hormone (AMH) (B = -0.009, P < 0.001). Our findings suggest that high BMI is negatively associated with semen characteristics and serum levels of AMH. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Public Library of Science | en_US |
dc.relation.ispartofseries | PloS one;10(6) | en_US |
dc.subject | Body mass index | en_US |
dc.subject | Sperm | en_US |
dc.subject | Semen | en_US |
dc.subject | Obesity | en_US |
dc.subject | Testosterone | en_US |
dc.subject | Sex hormons | en_US |
dc.subject | Androgens | en_US |
dc.subject | Luteinizing hormone | en_US |
dc.subject | VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nefrologi, urologi: 772 | en_US |
dc.subject | VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gynekologi og obstetrikk: 756 | en_US |
dc.title | Body Mass Index Is Associated with Impaired Semen Characteristics and Reduced Levels of Anti-Müllerian Hormone across a Wide Weight Range | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | Copyright: © 2015 Andersen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited | |
dc.identifier.doi | http://dx.doi.org/10.1371/journal.pone.0130210 | |